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Ehjcardiovascrec

Methods and results In C57/Bl6 mice, development of cardiac hypertrophy induced by transaortic constriction (TAC) for 5 weeks was reduced by ramipril, 5 mg/kg p.o., independent of blood pressure ...

Cardiovascular Research, Müller, Patrick, Kazakov, Andrey, Jagoda, Philippe, Semenov, Alexander, Böhm, Michael, Laufs, Ulrich

Date : 01/07/2009 Item size : 281049 bytes
Ehjcardiovascrec

Introduction Left ventricular hypertrophy (LVH) is a major risk factor for the development of heart failure and death [1]. Rac1 activation initiates a cascade of signal amplification involving ...

Cardiovascular Research, Custodis, Florian, Eberl, Marcel, Kilter, Heiko, Böhm, Michael, Laufs, Ulrich

Date : 15/07/2006 Item size : 303882 bytes
Ehjcardiovascrec

Abstract Abnormal intracellular Ca2+-handling appears to be a major cause of systolic and diastolic dysfunction in animals and humans with cardiac hypertrophy due to pressure overload and heart ...

Cardiovascular Research, Zolk, Oliver, Flesch, Markus, Nickenig, Georg, Schnabel, Petra, Böhm, Michael

Date : 01/07/1998 Item size : 667449 bytes
Ehjcardiovascrec

Methods and results Ten-week-old male C57/Bl6 wild-type (WT) and eNOS mice (eNOS were subjected to transverse aortic constriction (TAC, 360 μm, 35 days) or sham operation inducing cardiac ...

Cardiovascular Research, Kazakov, Andrey, Müller, Patrick, Jagoda, Philippe, Semenov, Alexander, Böhm, Michael, Laufs, Ulrich

Date : 01/03/2012 Item size : 274600 bytes
Ehjcardiovascrec

In addition to cholesterol-lowering, statins inhibit the isoprenylation of small G proteins. [...]it was tested if these drugs inhibit Rac1 and RhoA activity in cardiomyocytes and, thereby, prevent ...

Cardiovascular Research, Laufs, Ulrich, Kilter, Heiko, Konkol, Christian, Wassmann, Sven, Böhm, Michael, Nickenig, Georg

Date : 01/03/2002 Item size : 280897 bytes
Ehjcardiovascrec

Methods and results Pressure overload induced by transaortic constriction (TAC, C57/Bl6 mice, 360 µm for 35 days) increased left ventricular (LV) systolic pressure, the ratio of heart weight to ...

Cardiovascular Research, Müller, Patrick, Kazakov, Andrey, Semenov, Alexander, Böhm, Michael, Laufs, Ulrich

Date : 01/01/2008
Ehjcardiovascrec

Methods and results In C57/Bl6 mice, development of cardiac hypertrophy induced by transaortic constriction (TAC) for 5 weeks was reduced by ramipril, 5 mg/kg p.o., independent of blood pressure ...

Cardiovascular Research, Müller, Patrick, Kazakov, Andrey, Jagoda, Philippe, Semenov, Alexander, Böhm, Michael, Laufs, Ulrich

Date : 01/07/2009
Ehjcardiovascrec

In addition to cholesterol-lowering, statins inhibit the isoprenylation of small G proteins. [...]it was tested if these drugs inhibit Rac1 and RhoA activity in cardiomyocytes and, thereby, prevent ...

Cardiovascular Research, Laufs, Ulrich, Kilter, Heiko, Konkol, Christian, Wassmann, Sven, Böhm, Michael, Nickenig, Georg

Date : 01/03/2002
Ehjcardiovascrec

Methods and results Ten-week-old male C57/Bl6 wild-type (WT) and eNOS mice (eNOS were subjected to transverse aortic constriction (TAC, 360 μm, 35 days) or sham operation inducing cardiac ...

Cardiovascular Research, Kazakov, Andrey, Müller, Patrick, Jagoda, Philippe, Semenov, Alexander, Böhm, Michael, Laufs, Ulrich

Date : 01/03/2012 Item size : 271786 bytes
Ehjcardiovascrec

Abstract Objective: To characterize the cardiac angiotensin and endothelin (ET) system in compensated left ventricular hypertrophy due to long standing arterial hypertension and to assess the role of ...

Cardiovascular Research, Zolk, Oliver, Quattek, Jessika, Seeland, Ute, El-Armouche, Ali, Eschenhagen, Thomas, Böhm, Michael

Date : 01/02/2002