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[6],[7] Nevertheless, patients with HF present increased variability in metabolism of vitamin K antagonists (VKAs), which is reflected in a poorer international normalized ratio (INR) control[8] and ...

European Journal of Heart Failure, Ferreira, Jorge, Ezekowitz, Michael D., Connolly, Stuart J., Brueckmann, Martina, Fraessdorf, Mandy, Reilly, Paul A., Yusuf, Salim, Wallentin, Lars

Date : 01/09/2013 Item size : 196745 bytes

In patients with recently decompensated congestive heart failure (CHF) and depressed LV function, the drug was associated with excess mortality compared with a placebo group. Methods and results We ...

European Heart Journal, Hohnloser, Stefan H., Crijns, Harry J.G.M., van Eickels, Martin, Gaudin, Christophe, Page, Richard L., Torp-Pedersen, Christian, Connolly, Stuart J.

Date : 01/07/2010

Table 1 Studies examining the relationship between atrial fibrillation and all-cause mortality Study Cohort Adjusted relative risk of death (95% CI)  Andersson1  272 186 incident ...

European Heart Journal, Leong, Darryl P., Eikelboom, John W., Healey, Jeff S., Connolly, Stuart J.

Date : 07/04/2013 Item size : 160238 bytes

The IMPACT trial was prematurely terminated for futility, after 63 primary events among 1357 patients in the intervention arm and 61 events among 1361 patients in the control arm; hazard ratio (HR) ...

European Heart Journal, Healey, Jeff S., Lopes, Renato D., Connolly, Stuart J.

Date : 07/07/2015 Item size : 144243 bytes

NOACs are at least as effective and safe as warfarin while allowing convenient fixed dosing regimens.1,2 Moreover, due to their rapid onset and offset of action,3 NOACs have the potential to simplify ...

European Heart Journal, Vanassche, Thomas, Lauw, Mandy N., Connolly, Stuart J., Eikelboom, John W.

Date : 21/07/2014 Item size : 134108 bytes

Abstract Aims The aim of this study was to evaluate the effects of apixaban, a novel oral factor Xa inhibitor, on the need for cardiovascular hospitalization. Methods and results Our analysis is ...

European Heart Journal, Hohnloser, Stefan H., Shestakovska, Olga, Eikelboom, John, Franzosi, Maria Grazia, Tan, Ru San, Zhu, Jun, Yusuf, Salim, Connolly, Stuart J.

Date : 14/09/2013 Item size : 209869 bytes

Conclusion In a large population of non-anticoagulated AF patients, pattern of AF was a strong independent predictor of stroke risk and may be helpful to assess the risk/benefit for anticoagulant ...

European Heart Journal, Vanassche, Thomas, Lauw, Mandy N., Eikelboom, John W., Healey, Jeff S., Hart, Robert G., Alings, Marco, Avezum, Alvaro, Díaz, Rafael, Hohnloser, Stefan H., Lewis, Basil S., ...

Date : 01/02/2015 Item size : 328635 bytes

Whereas it is well appreciated that stroke risk in end-stage renal disease is elevated,4 the issue of AF-associated thrombo-embolic risk is more controversial in patients with CKD not on renal ...

European Heart Journal, Hohnloser, Stefan H., Connolly, Stuart J.

Date : 01/10/2011

Methods and results Patients with AF and more than one risk factor for stroke were randomized to one of three blinded doses of betrixaban (40, 60, or 80 mg once daily) or unblinded warfarin, adjusted ...

European Heart Journal, Connolly, Stuart J., Eikelboom, John, Dorian, Paul, Hohnloser, Stefan H., Gretler, Daniel D., Sinha, Uma, Ezekowitz, Michael D.

Date : 21/05/2013

Abstract Aims The CHA2DS2-VASc score is a modification of the CHADS2 score that aims to improve stroke risk prediction in patients with atrial fibrillation (AF) by adding three risk factors: age ...

European Heart Journal, Coppens, Michiel, Eikelboom, John W., Hart, Robert G., Yusuf, Salim, Lip, Gregory Y.H., Dorian, Paul, Shestakovska, Olga, Connolly, Stuart J.

Date : 14/01/2013 Item size : 240423 bytes