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For a detailed consideration of physiological vs. pathological hypertrophy (see Dorn, 2007).], resulting from volume overload-induced cardiomyocyte lengthening, without activation of foetal genes3 ...

Cardiovascular Research, Review, Elizabeth A. Woodcock, Xiao-Jun Du, Melissa E. Reichelt, Robert M. Graham

Date : 01/02/2008 Item size : 499739 bytes

Pharmacological studies have established that a blockade of the RAS at the level of the angiotensin-converting enzyme (ACE) or the AT1-receptor ameliorates the remodeling process of the heart and ...

Cardiovascular Research, Review, Kai C Wollert, Helmut Drexler

Date : 01/09/1999 Item size : 591071 bytes

Long‐term severe diabetes only leads to mild cardiac diastolic dysfunction in Zucker diabetic fatty rats Introduction It is generally accepted that diabetes mellitus (DM) increases the risk for ...

European Journal of Heart Failure, Daniels, Anneleen, Linz, Dominik, Bilsen, Marc, Rütten, Hartmut, Sadowski, Thorsten, Ruf, Sven, Juretschke, Hans‐Paul, Neumann‐Haefelin, Claudia, Munts, ...

Date : 01/02/2012 Item size : 193393 bytes

[...]we present an algorithm for the stepwise assessment of myocardial phenotypes applicable to animal models using well-established imaging techniques and propose a list of parameters most suited ...

European Journal of Heart Failure, Knöll, Ralph, Iaccarino, Guido, Tarone, Guido, Hilfiker‐Kleiner, Denise, Bauersachs, Johann, Leite‐Moreira, Adelino F., Sugden, Peter H., Balligand, Jean‐Luc

Date : 01/08/2011 Item size : 203865 bytes

Abstract Background: Costs for large animal studies have escalated. [...]there is a need to develop small animal models of non-ischemic cardiac failure and accurate non-invasive techniques that will ...

Cardiovascular Research, Original Article, Ernst R. Schwarz, Charles Pollick, Joan Dow, Mike Patterson, Yochai Birnbaum, Robert A. Kloner

Date : 01/07/1998 Item size : 267622 bytes

In adults, EPO is produced primarily in the kidney via an oxygen-sensing mechanism and stimulates erythroid progenitors in the bone marrow to increase red blood cell mass. The therapeutic relevance ...

Cardiovascular Research, Editorial, Qingping Feng

Date : 01/09/2006 Item size : 169639 bytes

Abstract The syndrome of congestive heart failure (CHF) is an entity of ever increasing clinical significance. Recent data from studies on human myocardial tissue obtained in the setting of cardiac ...

Cardiovascular Research, Review, Pieter P de Tombe

Date : 01/02/1998 Item size : 670835 bytes

Several studies, including investigations in humans, have clearly shown an important pathophysiological role of this pathway in the cardiovascular system and in disease states such as hypertension, ...

Cardiovascular Research, Editorial, Stephan L.M. Peters, Martin C. Michel

Date : 01/07/2007 Item size : 162404 bytes

[...]altered expression of PLB and SLN has been reported in many cardiac diseases. [...]SERCA2a is a major regulator of intracellular Ca2+ homeostasis, and changes in the expression and activity of ...

Cardiovascular Research, Review, Muthu Periasamy, Poornima Bhupathy, Gopal J. Babu

Date : 15/01/2008 Item size : 520644 bytes

About 50% of heart failure cases result from coronary artery disease with the remainder arising from non-ischaemic, and often unknown, etiologies. Myocyte loss or systolic dysfunction is typically ...

Cardiovascular Research, Review, Alan D Wickenden, Roger Kaprielian, Zamaneh Kassiri, James N Tsoporis, Robert Tsushima, Glenn I Fishman, Peter H Backx

Date : 01/02/1998 Item size : 664742 bytes