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For a detailed consideration of physiological vs. pathological hypertrophy (see Dorn, 2007).], resulting from volume overload-induced cardiomyocyte lengthening, without activation of foetal genes3 ...

Cardiovascular Research, Review, Elizabeth A. Woodcock, Xiao-Jun Du, Melissa E. Reichelt, Robert M. Graham

Date : 01/02/2008 Item size : 499739 bytes

Abstract Aims High mobility group box 1 (HMGB1) is an abundant and ubiquitous nuclear DNA-binding protein that has multiple functions dependent on its cellular location. Conclusion These results ...

Cardiovascular Research, Cardiac biology and remodelling, Akira Funayama, Tetsuro Shishido, Shunsuke Netsu, Taro Narumi, Shinpei Kadowaki, Hiroki Takahashi, Takuya Miyamoto, Tetsu Watanabe, ...

Date : 01/09/2013 Item size : 301103 bytes

Tel: +39 0458123706, Fax: +39 045914727, Email: Search for more papers by this author Rossi Andrea, Department of Biomedical and Surgical Sciences, Division of ...

European Journal of Heart Failure, Bergamini, Corinna, Cicoira, Mariantonietta, Rossi, Andrea, Vassanelli, Corrado

Date : 01/05/2009 Item size : 232799 bytes

[...]anti-fibrotic strategies are increasingly recognized as a promising approach in the prevention and treatment of heart failure. [...]dissecting the molecular mechanisms underlying the ...

Cardiovascular Research, Review, Esther E. Creemers, Yigal M. Pinto

Date : 01/02/2011 Item size : 426359 bytes

KeywordsCardiomyopathyHeart failureContractile functionRemodelingVentricular functionTime for primary review 33 days. 1 Introduction Heart failure was defined by Braunwald as the pathophysiologic ...

Cardiovascular Research, Review, Stefan Hein, Sawa Kostin, Annette Heling, Yoshi Maeno, Jutta Schaper

Date : 14/01/2000 Item size : 261696 bytes

Methods and results Cardiac-restricted NF-κB inhibition was achieved by expression of a stabilized IκBα mutant (IκBαΔN) in cells with an active α-myosin heavy chain (αMHC) ...

Cardiovascular Research, Original Article, Laura Zelarayan, Anke Renger, Claudia Noack, Maria-Patapia Zafiriou, Christina Gehrke, Roel van der Nagel, Rainer Dietz, Leon de Windt, Martin W. Bergmann

Date : 01/12/2009

Metformin inhibited cardiac fibrosis (fibrosis area/total heart area: 0.6 ± 0.3 vs. 3.6 ± 0.9%, P < 0.01) induced by pressure overload and improved cardiac diastolic function (left ventricular ...

Cardiovascular Research, Original Article, Han Xiao, Xiaowei Ma, Wei Feng, Yongnan Fu, Zhizhen Lu, Ming Xu, Qiang Shen, Yi Zhu, Youyi Zhang

Date : 01/08/2010

[...]administration of isoproterenol was followed by a blunted contractile response in isolated myocytes of TGTAC mice. Conclusion These results suggest that cardiac-specific overexpression of a ...

Cardiovascular Research, Original Article, Stephanie Grote-Wessels, Hideo A. Baba, Peter Boknik, Ali El-Armouche, Larissa Fabritz, Hans-Jörg Gillmann, Dana Kucerova, Marek Matus, Frank U. ...

Date : 01/08/2008

Introduction Numerous studies have demonstrated that heart failure and depression often coexist, and that depression is linked to the severity of heart failure symptoms.1,2 Heart failure and ...

Cardiovascular Research, Original Article, Koji Ito, Yoshitaka Hirooka, Ryuichi Matsukawa, Masatsugu Nakano, Kenji Sunagawa

Date : 01/01/2012

Introduction β-Adrenergic receptors (βAR) are important regulators of cardiac function, increasing the intracellular levels of cAMP and activating the cAMP-dependent protein kinase A (PKA).1,2 ...

Cardiovascular Research, ORIGINAL ARTICLES: FOCUS ON MITOCHONDRIA IN CARDIAC DISEASE, Cinzia Perrino, Antonio Feliciello, Gabriele G. Schiattarella, Giovanni Esposito, Rosalia Guerriero, Laura ...

Date : 01/10/2010