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Consistent with a role in promoting necroptosis, adenoviral overexpression of RIP3 in neonatal rat cardiomyocytes and stimulation with TNF-α induced the formation of a complex of RIP1 and ...

Cardiovascular Research, Cardiac biology and remodelling, Mark Luedde, Matthias Lutz, Natalie Carter, Justyna Sosna, Christoph Jacoby, Mihael Vucur, Jérémie Gautheron, Christoph Roderburg, ...

Date : 15/07/2014 Item size : 330213 bytes

Methods and results We used several types of cultured mouse, rat, and bovine cells from the cardiovascular system, and evaluated mitochondrial morphology, reactive oxygen species (ROS) levels, and ...

Cardiovascular Research, Original Article, Tianzheng Yu, Shey-Shing Sheu, James L. Robotham, Yisang Yoon

Date : 15/07/2008 Item size : 328023 bytes

Methods: The effect of several concentrations of KB-R7943 added at reperfusion was studied in Fura-2 loaded quiescent cardiomyocytes submitted to 40 min of simulated ischemia (NaCN 2 mM, pH 6.4), and ...

Cardiovascular Research, Original Article, Javier Inserte, David Garcia-Dorado, Marisol Ruiz-Meana, Ferran Padilla, José A Barrabés, Pilar Pina, Luis Agulló, Hans Michael Piper, Jordi ...

Date : 01/09/2002 Item size : 271773 bytes

Abstract Objective: The cytokine cardiotrophin-1 (CT-1) has previously been shown to protect cultured cardiocytes from cell death induced by serum removal or hypoxia when administered prior to the ...

Cardiovascular Research, Original Article, Bhawanjit K Brar, Anastasis Stephanou, Zhihong Liao, Rhona M O'Leary, Diane Pennica, Derek M Yellon, David S Latchman

Date : 01/08/2001 Item size : 297331 bytes

Abstract Macrophages play a key role in atherosclerotic plaque destabilization and rupture. [...]macrophages are phagocytic cells and thus have an important additional role in scavenging of modified ...

Cardiovascular Research, Review, Dorien M. Schrijvers, Guido R.Y. De Meyer, Arnold G. Herman, Wim Martinet

Date : 01/02/2007 Item size : 443225 bytes

Methods Intracellular Na+ concentration ([Na+]i) measured using 23Na-magnetic resonance spectroscopy, Na+/K+-ATPase activity, detachment of Na+/K+-ATPase α subunits from the membrane cytoskeleton, ...

Cardiovascular Research, Original Article, Javier Inserte, David Garcia-Dorado, Victor Hernando, Ignasi Barba, Jordi Soler-Soler

Date : 01/05/2006 Item size : 287033 bytes

Introduction Nearly twenty years after its initial description, the phenomenon of ischemic preconditioning, whereby episodes of intermittent sublethal ischemia and reperfusion confer resistance ...

Cardiovascular Research, Review, Derek J. Hausenloy, Derek M. Yellon

Date : 01/05/2006 Item size : 525135 bytes

Endothelial cell biology and pathology Once viewed as a passive inner cover of the vessel wall, the endothelium is now recognized as an active organ with many important functions, such as regulation ...

Cardiovascular Research, Review, Gian Paolo Fadini, Angelo Avogaro

Date : 01/07/2010 Item size : 471363 bytes

Mitochondria have been implicated in the loss of cells in various cardiac pathologies, including ischaemia/reperfusion injury, cardiomyopathy, and congestive heart failure. The strategic positioning ...

Cardiovascular Research, Review, Åsa B. Gustafsson, Roberta A. Gottlieb

Date : 15/01/2008 Item size : 598788 bytes

Abstract This brief review summarizes the recently obtained evidence which illustrates the beneficial effects of the endogenously produced antioxidant, melatonin, in reducing tissue damage and ...

Cardiovascular Research, Review, Russel J. Reiter, Dun-Xian Tan

Date : 01/04/2003 Item size : 397783 bytes