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Rapamycin also impaired cell mobility, as assessed by a wound test, and promoted the formation of actin stress fibres, as determined with confocal microscopy. [...]the inhibitor prolonged ...

Cardiovascular Research, Original Article, Amelia Barilli, Rossana Visigalli, Roberto Sala, Gian C. Gazzola, Alessandro Parolari, Elena Tremoli, Sabrina Bonomini, Alexandra Simon, Ellen I. Closs, ...

Date : 01/06/2008 Item size : 295259 bytes

Abstract Several pathologies of the cardiovascular system are associated with an augmented production of nitric oxide and/or superoxide-derived oxidants and/or alteration in the antioxidant ...

Cardiovascular Research, Review, Gonzalo Peluffo, Rafael Radi

Date : 15/07/2007 Item size : 511451 bytes

Abstract Nitric oxide (NO) generated constitutively within the heart has long been known to influence myocardial function; however, the precise nature of these effects has been controversial at least ...

Cardiovascular Research, Review, Mike Seddon, Ajay M. Shah, Barbara Casadei

Date : 15/07/2007 Item size : 427884 bytes

Introduction Nearly twenty years after its initial description, the phenomenon of ischemic preconditioning, whereby episodes of intermittent sublethal ischemia and reperfusion confer resistance ...

Cardiovascular Research, Review, Derek J. Hausenloy, Derek M. Yellon

Date : 01/05/2006 Item size : 525135 bytes

There are increasing data indicating that NO modulates various proteins involved in excitationcontraction coupling (ECC), and here we discuss the evidence that NO may modulate the function of the ...

Cardiovascular Research, Review, Gregory Lim, Luigi Venetucci, David A. Eisner, Barbara Casadei

Date : 15/01/2008 Item size : 401558 bytes

KeywordsBlood pressureCell communicationEndothelial factorsRenal functionTime for primary review 26 days. 1 Introduction There is a widely held view that function of the kidney is the key to ...

Cardiovascular Research, Review, Yuri Kotelevtsev, David J Webb

Date : 15/08/2001 Item size : 344637 bytes

Abstract Objective: We tested the hypothesis that occlusion of the superior mesenteric artery induces late preconditioning against myocardial infarction and examined the effects of pharmacological ...

Cardiovascular Research, Original Article, You-Ping Wang, Hui Xu, Kazuhiro Mizoguchi, Masahiro Oe, Hajime Maeta

Date : 01/02/2001 Item size : 266841 bytes

With the increased interest in using nitric oxide therapy to treat a number of human diseases, the understanding of the physiological properties unique to peroxynitrite as an important nitric oxide ...

Cardiovascular Research, Review, Russell S Ronson, Masanori Nakamura, Jakob Vinten-Johansen

Date : 01/10/1999 Item size : 442561 bytes

Abstract It is well recognized that insulin resistance found in patients with type 2 diabetes and obesity is a major risk factor for cardiovascular disease. Since its discovery in the 1920s, insulin ...

Cardiovascular Research, REVIEWS: FOCUS ON INORGANIC NITRITE AND NITRATE, Qiujun Yu, Feng Gao, Xin L. Ma

Date : 15/02/2011 Item size : 415186 bytes

Seminal studies from different laboratories identified the gaseous free radical NO to be the elusive EDRF (endothelial-derived relaxing factor) which is central in regulating vascular tone and was ...

Cardiovascular Research, REVIEWS: FOCUS ON INORGANIC NITRITE AND NITRATE, Christopher B. Pattillo, Shyamal Bir, Venkat Rajaram, Christopher G. Kevil

Date : 15/02/2011 Item size : 516125 bytes