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The antihypertensive drug amlodipine (Norvasc®) is a long-acting, third-generation Ca2+ channel blocker that has been shown to limit the progression of atherosclerosis and to decrease the ...

Cardiovascular Research, Editorial, Bernd Mayer

Date : 01/08/2006 Item size : 170032 bytes

Abstract Objectives: We tested the hypothesis that endothelin-1 (ET-1) aggravates ischaemia/reperfusion injury by stimulating cellular L-arginine depletion, which would result in reduced synthesis of ...

Cardiovascular Research, Original Article, Friedrich Brunner, Bernhard Leonhard, Walter R Kukovetz, Bernd Mayer

Date : 01/10/1997 Item size : 178923 bytes

Abstract Objective: The role of nitric oxide (NO) in myocardial ischemia/reperfusion injury remains controversial as both NO donors and NO synthase (NOS) inhibitors have shown to be ...

Cardiovascular Research, Original Article, Friedrich Brunner, Robert Maier, Penelope Andrew, Gerald Wölkart, Rudolf Zechner, Bernd Mayer

Date : 01/01/2003

Abstract Aims Nitroglycerin (GTN) acts through release of a nitric oxide (NO)-related activator of soluble guanylate cyclase in vascular smooth muscle. Besides enzymatic GTN bioactivation catalysed ...

Cardiovascular Research, Original Article, Gerald Wölkart, M. Verena Wenzl, Matteo Beretta, Heike Stessel, Kurt Schmidt, Bernd Mayer

Date : 15/07/2008

Abstract Objective: l-Ascorbic acid has been described to exert multiple beneficial effects in cardiovascular disorders associated with impaired nitric oxide (NO)/cGMP signalling. The aim of the ...

Cardiovascular Research, Original Article, Astrid Schrammel, Doris Koesling, Kurt Schmidt, Bernd Mayer

Date : 18/08/2000

In their comment to our recent study on the development of vascular tolerance to nitroglycerin (GTN) upon long-term ascorbate deprivation of guinea pigs,1 Daiber and Gori suggest that our data are in ...

Cardiovascular Research, Letter to the Editor, Bernd Mayer

Date : 01/09/2008