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There is mounting evidence that thrombin acts as a powerful modulator of many processes like regulation of vascular tone, permeability, migration and proliferation of VSMC, recruitment of monocytes ...

Cardiovascular Research, Review, Julian Ilcheff Borissoff, Henri M.H. Spronk, Sylvia Heeneman, Hugo ten Cate

Date : 01/06/2009 Item size : 584450 bytes

Abstract Several pathologies of the cardiovascular system are associated with an augmented production of nitric oxide and/or superoxide-derived oxidants and/or alteration in the antioxidant ...

Cardiovascular Research, Review, Gonzalo Peluffo, Rafael Radi

Date : 15/07/2007 Item size : 511451 bytes

Abstract It is well recognized that insulin resistance found in patients with type 2 diabetes and obesity is a major risk factor for cardiovascular disease. Since its discovery in the 1920s, insulin ...

Cardiovascular Research, REVIEWS: FOCUS ON INORGANIC NITRITE AND NITRATE, Qiujun Yu, Feng Gao, Xin L. Ma

Date : 15/02/2011 Item size : 415186 bytes

Of note, visible age-related signs such as male pattern boldness, grey hair, facial wrinkles as well as the presence of arcus corneae alone or in combination with appearance factors such as earlobe ...

European Heart Journal, Review, Giovanni G. Camici, Gianluigi Savarese, Alexander Akhmedov, Thomas F. Lüscher

Date : 21/12/2015 Item size : 709930 bytes

The role of reactive oxygen species and redox signalling in cardiovascular disease Reactive oxygen species (ROS) are generated during regulated physiological processes, and play a critical function ...

European Heart Journal, Clinical update, Keyvan Karimi Galougahi, Charalambos Antoniades, Stephen J. Nicholls, Keith M. Channon, Gemma A. Figtree

Date : 01/07/2015 Item size : 398285 bytes

Pathophysiogical aspects of platelet biology have, until recently, focussed on their relatively passive and reactive roles in minimising blood loss after injury, in contributing to the final stages ...

Cardiovascular Research, Editorial, Andrew D Blann

Date : 01/08/2004 Item size : 168301 bytes

An expanding body of evidence indicates that certain dietary patterns can influence cardiovascular health and primary prevention of CVD by modifying risk factors such as obesity, dyslipidemia, and ...

Cardiovascular Research, Editorial, Claudio Napoli, William C. Stanley, Louis J. Ignarro

Date : 15/01/2007 Item size : 226859 bytes

Animal as well as human studies have shown beneficial changes in biological phenomena related to cardiovascular health after the consumption of polyphenol-rich foods such as cocoa, red wine, tea, and ...

Cardiovascular Research, Editorial, José A. Páramo

Date : 01/07/2008 Item size : 165875 bytes

In addition to their lipid-lowering effects, one central biological action of statins is their ability to ameliorate the impaired bioavailability of NO.1 Mechanistically, this occurs through ...

Cardiovascular Research, Editorial, Stephan H. Schirmer, Christian M. Werner, Ulrich Laufs, Michael Böhm

Date : 01/06/2012 Item size : 181712 bytes

Convincing data from animal and in vitro models exist to indicate that endothelial dysfunction in diabetes may be related to hyperglycaemic pseudohypoxia, activation of protein kinase C, increased ...

Cardiovascular Research, Review, Coen D.A Stehouwer, Jan Lambert, A.J.M Donker, Victor W.M van Hinsbergh

Date : 01/04/1997 Item size : 262032 bytes