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Abstract Several pathologies of the cardiovascular system are associated with an augmented production of nitric oxide and/or superoxide-derived oxidants and/or alteration in the antioxidant ...

Cardiovascular Research, Review, Gonzalo Peluffo, Rafael Radi

Date : 15/07/2007 Item size : 511451 bytes

The beneficial actions of COX-2 appear to be mediated by the synthesis of PGE2 and/or PGI2. Since inhibition of iNOS in preconditioned myocardium blocks COX-2 activity whereas inhibition of COX-2 ...

Cardiovascular Research, Review, Roberto Bolli, Ken Shinmura, Xian-Liang Tang, Eitaro Kodani, Yu-Ting Xuan, Yiru Guo, Buddhadeb Dawn

Date : 15/08/2002 Item size : 570075 bytes

Abstract Endothelial production of nitric oxide (nitrogen monoxide, NO) has become a major research area in vascular biology. The aim of this review is to examine the cellular and molecular ...

Cardiovascular Research, Review, Michael T Gewaltig, Georg Kojda

Date : 01/08/2002 Item size : 486616 bytes

Abstract Objective: This study is aimed to explore whether gender plays a role in the generation of nitric oxide (NO) and superoxide anion (O2 in microvessels of hypertensive rats (SHR), as well as ...

Cardiovascular Research, Original Article, Ana Paula V Dantas, Maria do Carmo P Franco, Michele M Silva-Antonialli, Rita C.A Tostes, Zuleica B Fortes, Dorothy Nigro, Maria Helena C Carvalho

Date : 01/01/2004 Item size : 252323 bytes

In the vessels of healthy subjects, endothelial cells (ECs) of large conduit arteries express Cx37 and Cx40, whereas Cx43 and (to a much lower extent) Cx45 are mostly expressed by vascular smooth ...

Cardiovascular Research, SPOTLIGHT REVIEWS: SPOTLIGHT ON BIOMECHANICAL FACTORS IN CARDIOVASCULAR DISEASE, Merlijn J. Meens, Anna Pfenniger, Brenda R. Kwak, Mario Delmar

Date : 15/07/2013 Item size : 526340 bytes

Based on epidemiological studies, homocysteine (Hcy) is regarded as an independent risk indicator for occlusive vascular diseases [1,2]. Under experimental conditions, increased Hcy concentrations ...

Cardiovascular Research, Editorial, Andreas Deussen

Date : 01/08/2003 Item size : 187010 bytes

Abstract There is abundant evidence that the endothelium plays a crucial role in the maintenance of vascular tone and structure. ADMA is increased in the plasma of humans with hypercholesterolemia, ...

Cardiovascular Research, Review, Rainer H Böger

Date : 01/10/2003 Item size : 416586 bytes

[...]we will elucidate the potential benefits and limitations of S1P analogues as a new class of functional HDL mimetics for cardiovascular therapy. Pleiotropic effects of high-density lipoproteins ...

Cardiovascular Research, Review, Katherine Sattler, Bodo Levkau

Date : 01/05/2009 Item size : 690723 bytes

Mice lacking the endothelial isoform are hypertensive, have endothelial dysfunction and show a more severe outcome in response to vascular injury, to stroke and cerebral ischaemia, and to ...

Cardiovascular Research, REVIEW ARTICLES, Victor W.T. Liu, Paul L. Huang

Date : 01/01/2008 Item size : 592603 bytes

PDE1 and/or PDE5 are also reportedly up-regulated in chronic disease conditions such as atherosclerosis or cardiac pressure-load stress and heart failure as well as in response to long-term exposure ...

Cardiovascular Research, Review, David A. Kass, Eiki Takimoto, Takahiro Nagayama, Hunter C. Champion

Date : 15/07/2007 Item size : 466088 bytes