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Introduction Nearly twenty years after its initial description, the phenomenon of ischemic preconditioning, whereby episodes of intermittent sublethal ischemia and reperfusion confer resistance ...

Cardiovascular Research, Review, Derek J. Hausenloy, Derek M. Yellon

Date : 01/05/2006 Item size : 525135 bytes

Preconditioning, a series of transient intervals of ischaemia and reperfusion applied before the lethal index ischaemic event, sets in motion molecular and cellular mechanisms that increase ...

Cardiovascular Research, Review, Asger Granfeldt, David J. Lefer, Jakob Vinten-Johansen

Date : 15/07/2009 Item size : 648421 bytes

Evidence for the existence of apoptosis in the human heart has been reported in various cardiac diseases, including ischemic and non-ischemic heart failure, myocardial infarction and ...

Cardiovascular Research, Review, Giora Z. Feuerstein, Peter R. Young

Date : 01/02/2000 Item size : 352446 bytes

Ischemia/reperfusion-induced apoptosis: connecting nitric oxide and cell cycle regulators [...]serum stimulation of neonatal, terminally-differentiated cardiomyocytes, similarly to what happens in ...

Cardiovascular Research, Editorial, Carla Pignatti, Claudio Stefanelli

Date : 01/08/2003 Item size : 210601 bytes

[...]the role of mitochondria goes beyond their capacity to create molecular fuel, to include the generation of reactive oxygen species, the regulation of calcium, and activation of cell ...

Cardiovascular Research, REVIEWS: SPOTLIGHT ON SMOOTH MUSCLE CELLS AND VASCULAR DISEASES, Emma Yu, John Mercer, Martin Bennett

Date : 15/07/2012 Item size : 535453 bytes

[...]the role of the mitochondrial uncoupling proteins in ischaemia tolerance is discussed. Mitochondria are essential organelles in any tissue, but when oxygen availability is limited they can ...

Cardiovascular Research, REVIEWS: FOCUS ON MITOCHONDRIA IN CARDIAC DISEASE, Susana Cadenas, Julián Aragonés, Manuel O. Landázuri

Date : 01/11/2010 Item size : 633400 bytes

Introduction Acute renal failure (ARF) caused by renal ischemia/reperfusion (I/R) is an important clinical problem. Studies have shown that early I/R injury can lead to the initiation of ...

Cardiovascular Research, Review, Ajay Kher, Kirstan K. Meldrum, Meijing Wang, Ben M. Tsai, Jeffrey M. Pitcher, Daniel R. Meldrum

Date : 01/09/2005 Item size : 503747 bytes

Abstract Objectives Septic shock and sequential multiple organ failure remain the cause of death in septic patients. Synthetic small interfering RNAs (siRNAs) specifically suppress gene expression ...

Cardiovascular Research, Original Article, Naoyuki Matsuda, Yasuo Takano, Shun-ichiro Kageyama, Noboru Hatakeyama, Kiyoshi Shakunaga, Isao Kitajima, Mitsuaki Yamazaki, Yuichi Hattori

Date : 01/10/2007 Item size : 307264 bytes

Methods: Inducible nitric oxide synthase (iNOS) expression, cardiomyocyte calcium handling, mitochondrial energetics, and the activation of protective signalling pathways in response to IL-6 were ...

Cardiovascular Research, Original Article, Nicola Smart, Mart H. Mojet, David S. Latchman, Michael S. Marber, Michael R. Duchen, Richard J. Heads

Date : 01/01/2006 Item size : 304116 bytes

Abstract Although the specific roles of nitric oxide (NO) in the heart in general and on cardiac mitochondria in particular remain controversial, it is now clear that both endogenous and exogenous ...

Cardiovascular Research, Review, Sean M. Davidson, Michael R. Duchen

Date : 01/07/2006 Item size : 551284 bytes