Abstract It is well recognized that insulin resistance found in patients with type 2 diabetes and obesity is a major risk factor for cardiovascular disease. Since its discovery in the 1920s, insulin ...
Cardiovascular Research, Yu, Qiujun, Gao, Feng, Ma, Xin L.
When the Nobel prize for physiology and medicine was awarded for the discovery of the first peptide growth factors to Rita Levi-Montalcini and Stanley Cohen in 1986, Russel Ross in Seattle was among ...
Cardiovascular Research, Post, Mark, Waltenberger, Johannes
Abstract Objective: Vascular endothelial growth factor (VEGF) induces the release of nitric oxide (NO) from endothelial cells. Methods: To further investigate this interaction, we examined the ...
Cardiovascular Research, Jozkowicz, Alicja, Cooke, John P, Guevara, Ibeth, Huk, Ihor, Funovics, Philip, Pachinger, Otmar, Weidinger, Franz, Dulak, Jozef
Abstract Aims The chemokine receptor CXCR4 modulates endothelial progenitor cell migration, homing, and differentiation, and plays a key role in cardiovascular regeneration. In a mouse model of ...
European Heart Journal, Cencioni, Chiara, Melchionna, Roberta, Straino, Stefania, Romani, Marta, Cappuzzello, Claudia, Annese, Valentina, Wu, Joseph C., Pompilio, Giulio, Santoni, Angela, Gaetano, ...
Methods and results The atherosclerotic plaque model was established in New Zealand rabbits by balloon injury of abdominal arteries and a high cholesterol (1%) diet. Arginase I overexpression ...
European Heart Journal, Wang, Xu-Ping, Zhang, Wei, Liu, Xiao-Qian, Wang, Wen-Ke, Yan, Fei, Dong, Wen-Qian, Zhang, Yun, Zhang, Ming-Xiang
Estrogen receptor-α gene transfer into bovine aortic endothelial cells induces eNOS gene expression and inhibits cell migration Abstract Objectives: It has been suggested that estrogen may ...
Cardiovascular Research, Tan, Enqing, Gurjar, Milind V, Sharma, Ram V, Bhalla, Ramesh C
There was no increase in apoptosis detected in eNOS transduced cells after 24 or 72 h. Conclusion: eNOS gene transfer to vascular SMCs inhibits cell proliferation via upregulation of p27 and p21 ...
Cardiovascular Research, Sato, Junâichi, Nair, Kamala, Hiddinga, Jay, Eberhardt, Norman L., Fitzpatrick, Lorraine A., Katusic, Zvonimir S., OâBrien, Timothy
Abstract Aims Anti-platelet agents, such as dipyridamole, have several clinical benefits for peripheral artery disease with the speculation of angiogenic potential that could preserve ischaemic ...
Cardiovascular Research, Venkatesh, Prasanna K., Pattillo, Christopher B., Branch, Billy, Hood, Jay, Thoma, Steven, Illum, Sandra, Pardue, Sibile, Teng, Xinjun, Patel, Rakesh P., Kevil, Christopher G.
[...]increase in vessel wall thickness and hyperplasia were shown to occur following ligation of the carotid artery in NO synthase (eNOS) knockout mice suggesting NO to be a negative regulator of ...
Cardiovascular Research, Holt, Cathy M.
Following arterial injury, NO has been shown to serve many vasoprotective roles, including inhibition of platelet aggregation and adherence to the site of injury, inhibition of leukocyte adherence, ...
Cardiovascular Research, Kibbe, Melina, Billiar, Timothy, Tzeng, Edith