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Abstract Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O2 have been implicated in the pathogenesis of many cardiovascular diseases, including ...

Cardiovascular Research, Review, Tohru Fukai, Rodney J Folz, Ulf Landmesser, David G Harrison

Date : 01/08/2002 Item size : 408641 bytes

Atherosclerosis is epidemiologically linked and causally related to the presence of risk factors Despite their diversity, major risk factors for cardiovascular disease such as hypercholesterolaemia, ...

Cardiovascular Research, Editorial, Raffaele De Caterina, Rosalinda Madonna

Date : 01/03/2009 Item size : 231905 bytes

Heart failure (HF) is the leading cause of morbidity and mortality in industrialized countries with direct and indirect costs in 2012 across the globe of $108 billion per annum,1 making this ...

European Heart Journal, Review, Thomas Münzel, Tommaso Gori, John F. Keaney, Christoph Maack, Andreas Daiber

Date : 07/10/2015 Item size : 606980 bytes

In this study, we investigated the effect of elevated glucose concentrations on intracellular calcium (Ca2+i) signal transduction in response to stimulants of EDRF/nitric oxide release in cultured ...

Cardiovascular Research, Original Article, Galen M Pieper, Lynn Dondlinger

Date : 01/04/1997 Item size : 217987 bytes

Methods: In rat mesenteric arteries, isometric tension was recorded in wire myographs, protein expression was evaluated by Western blot and/or immunohistochemistry and NO concentration was measured ...

Cardiovascular Research, Original Article, Raquel Hernanz, María J Alonso, Helle Zibrandtsen, Yolanda Alvarez, Mercedes Salaices, Ulf Simonsen

Date : 01/04/2004 Item size : 295923 bytes

Abstract Aging is considered to be the major risk factor for the development of atherosclerosis and, therefore, for coronary artery disease. Apart from its vasodilator property, NO exerts inhibitory ...

Cardiovascular Research, Review, Ralf P. Brandes, Ingrid Fleming, Rudi Busse

Date : 01/05/2005 Item size : 563903 bytes

In the present study, we investigate whether ANG II can induce O2 release from human vascular endothelial cells (HVECs) and the possible mechanisms involved. Methods and Results: The expression of ...

Cardiovascular Research, Original Article, Hong Zhang, Alexander Schmeißer, Christoph D Garlichs, Katrin Plötze, Uwe Damme, Andreas Mügge, Werner G Daniel

Date : 01/10/1999

Abstract Objectives Recent studies have demonstrated that perivascular adipose tissue (PVAT) releases vascular relaxation factor(s). Conclusion These results show that PVAT enhances the arterial ...

Cardiovascular Research, Original Article, Yu-Jing Gao, Kumiko Takemori, Li-Ying Su, Wen-Sheng An, Chao Lu, Arya M. Sharma, Robert M.K.W. Lee

Date : 15/07/2006

Methods: BAEC were cocultured with phorbol 12-myristate 13-acetate (PMA)-activated human PMN (effector-to-target ratio, 10:1) and injury to BAEC was evaluated at intervals by 51Cr release ...

Cardiovascular Research, Original Article, Zhi Su, Hideyuki Ishida, Naoto Fukuyama, Rumen Todorov, Chokoh Genka, Hiroe Nakazawa

Date : 01/08/1998

Abstract Objective: l-Ascorbic acid has been described to exert multiple beneficial effects in cardiovascular disorders associated with impaired nitric oxide (NO)/cGMP signalling. The aim of the ...

Cardiovascular Research, Original Article, Astrid Schrammel, Doris Koesling, Kurt Schmidt, Bernd Mayer

Date : 18/08/2000