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The TIMIC study (1) as a randomized, double-blind, placebo controlled trial included 85 patients with myocarditis and chronic (>6 month) heart failure unresponsive to conventional therapy. The ...

Date : 01/07/2009

[...]the number of autoantibody-positive patients (42 with DCM and 31 with ICM) was rather small for subgroup analysis of outcome. [...]at baseline the ICM group was older, had lower LVEF, lower VO2 ...

Date : 01/02/2011

Experimental and clinical data indicate that in a large proportion of patients myocarditis and DCM represent the acute and subacute/chronic stages of an organ-specific cardiac autoimmune disease, ...

Date : 28/06/2013

Introduction Pericardial diseases are commonly encountered in clinical practice and may involve cardiologists as well as different sub-specialty settings such as rheumatology, infectious diseases, ...

Date : 25/03/2014

In this community-based Framingham Heart Study, Schnabel et al. investigated 11 different blood biomarkers (C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, ...

Date : 31/07/2013

The case Mutations in different genes encoding sarcomeric proteins are responsible for 50–60% of familial cases of hypertrophic cardiomyopathy (HCM); however, the genetic alterations causing ...

Date : 01/04/2015

(6) studied a total of 488 unrelated index HCM patients who underwent screening for myofilament gene mutations by direct deoxyribonucleic acid sequencing of 8 genes, including myosin binding protein ...

Date : 01/05/2010

The cardiovascular system appeared during animal evolution when diffusion alone was incapable to meet metabolic needs of organisms due to their increased size and complexity. With the emergence of ...

Date : 13/04/2010

To answer these questions, 12 obese patients (7 men, mean age 48.3 ± 2.3 yrs) with insulin treated type 2 diabetes mellitus (T2DM) were put on a very-lowcalorie diet (VLCD; 450 kcal/day) for a ...

Date : 30/11/2008

Background Recurrent pericarditis is a difficult clinical problem1,2 that affects up to 30% of patients after a first episode of acute pericarditis, and up to 50% of those with a first recurrence, if ...

Date : 31/03/2017