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When AP-1 or NFkB activations were inhibited by specific inhibitors of AP-1, PD-98059 (Erk1/2 inhibitor), or SP-600125 (JNK inhibitor), and also with an inhibitor of NFKB and PDTC, TWEAK effect was ...

Cardiovascular Research, Martínez-Miguel, Patricia, Medrano-Andrés, Diana, Griera-Merino, Mercedes, Ortiz, Alberto, Rodríguez-Puyol, Manuel, Rodríguez-Puyol, Diego, López-Ongil, Susana

Date : 01/02/2017 Item size : 403409 bytes

Carotid arteries undergo hypertrophic inward remodelling in response to partial or complete ligation in vivo , but the increase in media area and thickness and reduction in lumen diameter are ...

Cardiovascular Research, Boedtkjer, Ebbe, Bentzon, Jacob F., Dam, Vibeke S., Aalkjaer, Christian

Date : 01/08/2016 Item size : 470447 bytes

Abstract Canonical innate immune signalling involves complex cascades: multiple germline-encoded pattern recognition receptors rapidly recognize pathogen-associated or damage-associated molecular ...

Cardiovascular Research, Zhang, Yaxing, Huang, Zan, Li, Hongliang

Date : 01/11/2017 Item size : 737589 bytes

The number of diagnosed diabetes cases has doubled since 1980 due to the aging population and the rising incidence of risk factors, such as obesity.1 Cardiovascular diseases, which include heart ...

Cardiovascular Research, Kalfon, Roy, Koren, Lilach, Aviram, Sharon, Schwartz, Ortal, Hai, Tsonwin, Aronheim, Ami

Date : 01/02/2017 Item size : 438206 bytes

During ventricular remodelling following sustained periods of pressure overload, cardiac fibroblasts become activated and start producing excessive amounts of ECM proteins, such as fibrillar ...

Cardiovascular Research, Herum, Kate M., Lunde, Ida G., Skrbic, Biljana, Louch, William E., Hasic, Almira, Boye, Sigurd, Unger, Andreas, Brorson, Sverre-Henning, Sjaastad, Ivar, Tønnessen, Theis, ...

Date : 01/05/2015 Item size : 405776 bytes

Vasculogenesis, the de novo formation of endothelial cells (ECs) from mesodermal precursors, results in the formation of the primary vessels of the embryo.1,2 Angiogenesis is an essential process by ...

Cardiovascular Research, Wang, Xin, Ling, Chang Chun, Li, Liping, Qin, Yinyin, Qi, Jialing, Liu, Xiaoyu, You, Bo, Shi, Yunwei, Zhang, Jie, Jiang, Qiu, Xu, Hui, Sun, Cheng, You, Yiwen, Chai, Renjie, ...

Date : 01/05/2016 Item size : 361693 bytes

Previous studies have demonstrated that SH2B1 is involved in a variety of biological process, such as maintaining neuronal differentiation, regulating energy and glucose homeostasis, and promoting ...

Cardiovascular Research, Wu, Gang, Liu, Yu, Huang, He, Tang, Yanhong, Liu, Wanli, Mei, Yang, Wan, Nian, Liu, Xiaoxiong, Huang, Congxin

Date : 15/07/2015 Item size : 413625 bytes

Abstract Although the initiation, development, and maintenance of atrial fibrillation (AF) have been linked to alterations in myocyte redox state, the field lacks a complete understanding of the ...

Cardiovascular Research, Simon, Jillian N., Ziberna, Klemen, Casadei, Barbara

Date : 01/04/2016 Item size : 492393 bytes

Analysis of the spatio-temporal cardiac excitation patterns in the frequency and phase domains has demonstrated the importance of rotors in research models of AF, however, the dynamics and role of ...

Cardiovascular Research, Guillem, María S., Climent, Andreu M., Rodrigo, Miguel, Fernández-Avilés, Francisco, Atienza, Felipe, Berenfeld, Omer

Date : 01/04/2016 Item size : 529608 bytes

[...]it has become clear that the clinical factors predisposing to AF and the cellular and molecular mechanisms involved are extremely complex. [...]all AF-promoting and maintaining mechanisms are ...

Cardiovascular Research, Heijman, Jordi, Algalarrondo, Vincent, Voigt, Niels, Melka, Jonathan, Wehrens, Xander H.T., Dobrev, Dobromir, Nattel, Stanley

Date : 01/04/2016 Item size : 629318 bytes