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1 Introduction When surveying the literature with the intention of evaluating to which extent studies on animal models have contributed to the understanding of arrhythmia mechanisms in patients and ...

Cardiovascular Research, Review, Michiel J. Janse, Tobias Opthof, André G. Kléber

Date : 01/07/1998 Item size : 562183 bytes

Methods: Shear stress and statin effects in combination with TNF-α were determined in human umbilical vein endothelial cells by quantitative measurements of the steady-state levels and stability ...

Cardiovascular Research, Original Article, Johannes V. van Thienen, Joost O. Fledderus, Rob J. Dekker, Jakub Rohlena, Gerben A. van IJzendoorn, Neeltje A. Kootstra, Hans Pannekoek, Anton J.G. ...

Date : 01/11/2006 Item size : 296044 bytes

The atherosclerotic Yucatan animal model to study the arterial response after balloon angioplasty: the natural history of remodeling Abstract Objective: Remodeling in de novo atherosclerosis and in ...

Cardiovascular Research, Original Article, B.J.G.L de Smet, J van der Zande, Y.J.M van der Helm, R.E Kuntz, C Borst, M.J Post

Date : 01/07/1998 Item size : 223215 bytes

KeywordsBrain ischemiaAnimal modelsStrokeCirculatory arrestResuscitationTreatmentTime for primary review 28 days. 1 Introduction More than any other organ of the body, brain integrity depends on the ...

Cardiovascular Research, Review, Konstantin-Alexander Hossmann

Date : 01/07/1998 Item size : 693686 bytes

Abstract Aims Recent studies from our laboratory demonstrated that increased expression of the small GTP-binding protein RhoA and activation of the RhoA/rho kinase (ROCK) pathway play an important ...

Cardiovascular Research, Original Article, Hesham Soliman, Graham P. Craig, Prabhakar Nagareddy, Violet G. Yuen, Guorong Lin, Ujendra Kumar, John H. McNeill, Kathleen M. MacLeod

Date : 15/07/2008 Item size : 280187 bytes

Results: FCCP (10-1000 nM) caused significant dose-dependent increase in oxygen consumption. Introduction It is now clear that mitochondria are not only the site of oxidative phosphorylation and ...

Cardiovascular Research, Original Article, Jonathan P. Brennan, Roger G. Berry, Max Baghai, Michael R. Duchen, Michael J. Shattock

Date : 01/11/2006 Item size : 260354 bytes

An ideal animal model for any cardiovascular disease in humans should have five characteristics: (i) mimic the human disease, (ii) allow studies in chronic, stable disease, (iii) produce symptoms ...

Cardiovascular Research, Review, Sheila A Doggrell, Lindsay Brown

Date : 01/07/1998 Item size : 693819 bytes

The mouse has turned out to be an invaluable model for mammalian genetic modifications to mimic and analyse cardiovascular pathology. KeywordsPhenotypeMouseGene ...

Cardiovascular Research, Review, Pieter A Doevendans, Mat J. Daemen, Ebo D de Muinck, Jos F Smits

Date : 01/07/1998 Item size : 533368 bytes

Gradually over the last 12 years dogs and cats, the classical experimental animals in cardiovascular sciences, became unfashionable for a variety of reasons, some of them nonscientific (i.e., new ...

Cardiovascular Research, Leading Article, Wolfgang Schaper, Bernd Winkler

Date : 01/07/1998 Item size : 155344 bytes

The widely used model is the spontaneous hypertensive rat (SHR) with a polygenic determination of hypertension has been a useful tool for the study of pathophysiological alterations in hypertensive ...

Cardiovascular Research, Original Article, Oliver Zolk, Markus Flesch, Georg Nickenig, Petra Schnabel, Michael Böhm

Date : 01/07/1998 Item size : 587738 bytes