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The potential for clinical application to benefit patients with a variety of pathological conditions has led to an expansion in our knowledge concerning the pathophysiology of ischemia-reperfusion ...

Cardiovascular Research, Review, Derek M Yellon, Gary F Baxter, David Garcia-Dorado, Gerd Heusch, Mark S Sumeray

Date : 01/01/1998 Item size : 550548 bytes

Despite its overall beneficial effect, experimental myocardial reperfusion was associated with prominent arrhythmias, enzyme release, and other adverse phenomena that were grouped under the imprecise ...

Cardiovascular Research, Viewpoint Editorial, David Garcia-Dorado, Hans Michael Piper

Date : 01/01/2006 Item size : 186761 bytes

In myocardium, gap junction communication is altered during ischemia, which contributes to the development of arrhythmias, but still allows synchronization of the onset of rigor contracture in the ...

Cardiovascular Research, Review, David Garcia-Dorado, Marisol Ruiz-Meana, Ferran Padilla, Antonio Rodriguez-Sinovas, Maribel Mirabet

Date : 15/08/2002 Item size : 519924 bytes

Conclusion: These results indicate that inhibition of Na+H+ exchange during ischemia is necessary to limit myocardial necrosis secondary to transient coronary occlusion, and that this action could be ...

Cardiovascular Research, Original Article, David Garcia-Dorado, Miguel A González, José A Barrabés, Marisol Ruiz-Meana, Julia Solares, Rosa-Maria Lidon, José Blanco, Yolanda Puigfel, ...

Date : 01/07/1997

The purpose of this study was to determine whether stimulation of particulate guanylyl cyclase with the natriuretic peptide urodilatin, given at the time of reperfusion, reduces myocardial necrosis ...

Cardiovascular Research, Original Article, Javier Inserte, David Garcia-Dorado, Luis Agulló, Amaya Paniagua, Jordi Soler-Soler

Date : 14/01/2000

Methods: Calpain activity and degradation of different structural proteins were studied along with the extent of necrosis in isolated rat hearts submitted to 60 min of ischemia and 30 min of ...

Cardiovascular Research, Research Article, Javier Inserte, David Garcia-Dorado, Marisol Ruiz-Meana, Luis Agulló, Pilar Pina, Jordi Soler-Soler

Date : 01/10/2004

Initially thought to participate only in propagation of the electrical impulse, Cx43 gap junction channels were later shown to mediate metabolic coupling between neighbouring cells, and to associate ...

Cardiovascular Research, Editorial, David Garcia-Dorado, Marisol Ruiz-Meana, Antonio Rodríguez-Sinovas

Date : 01/07/2014

The present study tested the hypothesis that l-arginine supplementation, at doses used in patients [15], protects myocardium against necrosis induced by transient coronary occlusion by preventing ...

Cardiovascular Research, Original Article, Ferran Padilla, David Garcia-Dorado, Luis Agulló, Javier Inserte, Amaya Paniagua, Sonia Mirabet, José A. Barrabés, Marisol Ruiz-Meana, Jordi ...

Date : 01/06/2000