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Ehjcardiovascrec

Methods: The effect of several concentrations of KB-R7943 added at reperfusion was studied in Fura-2 loaded quiescent cardiomyocytes submitted to 40 min of simulated ischemia (NaCN 2 mM, pH 6.4), and ...

Cardiovascular Research, Original Article, Javier Inserte, David Garcia-Dorado, Marisol Ruiz-Meana, Ferran Padilla, José A Barrabés, Pilar Pina, Luis Agulló, Hans Michael Piper, Jordi ...

Date : 01/09/2002 Item size : 271773 bytes
Ehjcardiovascrec

Abstract Aims It has been shown that sarcoplasmic reticulum calcium ATPase (SERCA) plays a critical role in reperfusion injury. [...]ischaemic post-conditioning (PoCo) results in protein kinase G ...

Cardiovascular Research, Cardiac biology and remodelling, Javier Inserte, Víctor Hernando, Marisol Ruiz-Meana, Marcos Poncelas-Nozal, Celia Fernández, Luis Agulló, Carmem Sartorio, Úrsula ...

Date : 01/09/2014 Item size : 366352 bytes
Ehjcardiovascrec

[...]SR and mitochondria interact physiologically to control cellular Ca2+ homeostasis. Alterations in the function of the SR are now known to be of primary importance for the development of ...

Cardiovascular Research, Editorial, David Garcia-Dorado, Hans Michael Piper, David A. Eisner

Date : 15/01/2008 Item size : 191287 bytes
Ehjcardiovascrec

Despite its overall beneficial effect, experimental myocardial reperfusion was associated with prominent arrhythmias, enzyme release, and other adverse phenomena that were grouped under the imprecise ...

Cardiovascular Research, Viewpoint Editorial, David Garcia-Dorado, Hans Michael Piper

Date : 01/01/2006 Item size : 186761 bytes
Ehjcardiovascrec

Methods and results Pigs were submitted to 40 min of coronary occlusion followed by reperfusion, and received (i) no treatment, (ii) one of the following treatments: RIC (5 min ischemia/5 min ...

Cardiovascular Research, Original Article, Juan José Alburquerque-Béjar, Ignasi Barba, Javier Inserte, Elisabet Miró-Casas, Marisol Ruiz-Meana, Marcos Poncelas, Úrsula Vilardosa, Laura ...

Date : 15/07/2015 Item size : 344631 bytes
Ehjcardiovascrec

Introduction In patients with ST-segment elevation acute myocardial infarction (AMI), the main therapeutic goal is to restore coronary flow as soon as possible by means of percutaneous intervention ...

Cardiovascular Research, Review, Javier Inserte, José A. Barrabés, Víctor Hernando, David Garcia-Dorado

Date : 15/07/2009 Item size : 489326 bytes
Ehjcardiovascrec

Methods and results The effect of acidic perfusion on reperfusion injury was studied in isolated rat hearts submitted to 40 min of ischaemia and 30 min of reperfusion, and its effect on the ...

Cardiovascular Research, ORIGINALS, Javier Inserte, Ignasi Barba, Víctor Hernando, Arancha Abellán, Marisol Ruiz-Meana, Antonio Rodríguez-Sinovas, David Garcia-Dorado

Date : 01/03/2008
Ehjcardiovascrec

[...]the so-called Ca2+ paradox (hypercontracture and death of cardiomyocytes occurring upon restoration of Ca2+ after a Ca2+-free perfusion period) was meant to be a first cellular model of ...

Cardiovascular Research, REVIEWS: SPOTLIGHT ON REDUCING MYOCARDIAL ISCHAEMIA/REPERFUSION INJURY, David Garcia-Dorado, Marisol Ruiz-Meana, Javier Inserte, Antonio Rodriguez-Sinovas, Hans Michael Piper

Date : 01/05/2012
Ehjcardiovascrec

The purpose of this study was to determine whether stimulation of particulate guanylyl cyclase with the natriuretic peptide urodilatin, given at the time of reperfusion, reduces myocardial necrosis ...

Cardiovascular Research, Original Article, Javier Inserte, David Garcia-Dorado, Luis Agulló, Amaya Paniagua, Jordi Soler-Soler

Date : 14/01/2000
Ehjcardiovascrec

The mechanisms of protection by postconditioning include: formation and release of several autacoids and cytokines; maintained acidosis during early reperfusion; activation of protein kinases; ...

Cardiovascular Research, Review, Michel Ovize, Gary F. Baxter, Fabio Di Lisa, Péter Ferdinandy, David Garcia-Dorado, Derek J. Hausenloy, Gerd Heusch, Jakob Vinten-Johansen, Derek M. Yellon, Rainer ...

Date : 01/08/2010