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Ehjcardiovascrec

Changes in mitochondrial morphology are regulated by the mitochondrial fusion proteins (mitofusins 1 and 2, and optic atrophy 1) and the mitochondrial fission proteins (dynamin-related peptide 1 and ...

Cardiovascular Research, Ong, Sang-Bing, Hausenloy, Derek J.

Date : 01/10/2010 Item size : 508719 bytes
Ehjcardiovascrec

The research article which attracted our attention was by two pioneers in MPTP research, Fabio Di Lisa and Paulo Bernardi at the University of Padova.1 In their experimental study, they had ...

Cardiovascular Research, Hausenloy, Derek J., Maddock, Helen L., Baxter, Gary F., Yellon, Derek M.

Date : 01/11/2012 Item size : 237670 bytes
Ehjcardiovascrec

Methods and results Our data showed that the isolated hearts of aged, diabetic Goto-Kakizaki rats were more susceptible to sub-lethal injury and not amenable to cardioprotection via IPC, compared ...

Cardiovascular Research, Whittington, Hannah J., Harding, Idris, Stephenson, Clemency I.M., Bell, Robert, Hausenloy, Derek J., Mocanu, Mihaela M., Yellon, Derek M.

Date : 01/09/2013 Item size : 339980 bytes
Ehjcardiovascrec

Methods and results Stabilization of myocardial HIF-1 was achieved by pharmacological inhibition of prolyl hydroxylase (PHD) domain-containing enzyme using GSK360A or using cardiac-specific ablation ...

Cardiovascular Research, Ong, Sang-Ging, Lee, Won Hee, Theodorou, Louise, Kodo, Kazuki, Lim, Shiang Y., Shukla, Deepa H., Briston, Thomas, Kiriakidis, Serafim, Ashcroft, Margaret, Davidson, Sean M., ...

Date : 01/10/2014
Ehjcardiovascrec

Introduction Elucidating the mechanistic pathways underlying normal cardiac development, growth, and differentiation has resulted in the identification of a variety of growth factors, each capable of ...

Cardiovascular Research, Hausenloy, Derek J., Yellon, Derek M.

Date : 15/07/2009
Ehjcardiovascrec

Introduction New treatment strategies are required to reduce myocardial injury and improve clinical outcomes in patients with coronary heart disease, the leading cause of death worldwide. Following ...

Cardiovascular Research, Hausenloy, Derek J., Yellon, Derek M.

Date : 01/08/2008
Ehjcardiovascrec

Introduction Nearly twenty years after its initial description, the phenomenon of ischemic preconditioning, whereby episodes of intermittent sublethal ischemia and reperfusion confer resistance ...

Cardiovascular Research, Hausenloy, Derek J., Yellon, Derek M.

Date : 01/05/2006 Item size : 661828 bytes
Ehjcardiovascrec

Time for primary review 18 days 1 Introduction Ischemic preconditioning (IPC), first described by Murry and co-workers in 1986 [1] as an effective endogenous protective phenomenon whereby exposure to ...

Cardiovascular Research, Lim, Shiang Y., Davidson, Sean M., Hausenloy, Derek J., Yellon, Derek M.

Date : 01/08/2007 Item size : 224487 bytes
Ehjcardiovascrec

During the last three decades, a wide variety of ischaemic conditioning strategies and pharmacological treatments have been tested in the clinichowever, their translation from experimental to ...

Cardiovascular Research, Hausenloy, Derek J., Garcia-Dorado, David, Bøtker, Hans Erik, Davidson, Sean M., Downey, James, Engel, Felix B., Jennings, Robert, Lecour, Sandrine, Leor, Jonathan, ...

Date : 01/05/2017
Ehjcardiovascrec

Abstract Aims It has been suggested that mitochondrial reactive oxygen species (ROS), Akt and Erk1/2 and more recently the mitochondrial permeability transition pore (mPTP) may act as mediators of ...

Cardiovascular Research, Hausenloy, Derek J., Lim, Shiang Y., Ong, Sang-Ging, Davidson, Sean M., Yellon, Derek M.

Date : 01/10/2010