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Abstract Objective: In isolated cardiac preparations of non-failing hearts from different species, including man, there is a positive forcefrequency relation which is reversed into a negative ...

Cardiovascular Research, Neumann, Till, Ravens, Ursula, Heusch, Gerd

Date : 01/02/1998 Item size : 368386 bytes

[...]the coronary microcirculation is also a target of both injury by myocardial ischaemia/reperfusion and protection from it. Starting with Jim Downey's original observation of a causal role for ...

Cardiovascular Research, Heusch, Gerd, Kleinbongard, Petra, Skyschally, Andreas, Levkau, Bodo, Schulz, Rainer, Erbel, Raimund

Date : 01/05/2012 Item size : 528789 bytes

Abstract Objective: The role of p38MAPK in ischemic preconditioning (IP) is still equivocal, insofar as the p38MAPK-inhibitor SB203580 abolished IP in rats, rabbits and dogs, but not in pigs. In ...

Cardiovascular Research, Schulz, Rainer, Belosjorow, Sergej, Gres, Petra, Jansen, Johanna, Michel, Martin C, Heusch, Gerd

Date : 15/08/2002 Item size : 290598 bytes

The signal transduction for protection from lethal reperfusion injury is still under intense debate.18 Yellon et al. have identified a concerted program of intracellular protein kinase activation ...

Cardiovascular Research, Heusch, Gerd

Date : 01/11/2009 Item size : 197656 bytes

Ischaemic pre and postconditioning are powerful cardioprotective phenomena, in which infarct size is reduced by one or several short episodes of myocardial ischaemia with reperfusion preceding or ...

Cardiovascular Research, Boengler, Kerstin, Schulz, Rainer, Heusch, Gerd

Date : 15/07/2009

Abstract Objective: Short-term myocardial hibernation is characterized by an adaptation of contractile function to the reduced blood flow, the recovery of creatine phosphate content and lactate ...

Cardiovascular Research, Martin, Claus, Schulz, Rainer, Rose, Jochen, Heusch, Gerd

Date : 01/08/1998 Item size : 355727 bytes

In the context of coronary artery disease, myocardial hibernation was originally seen as a chronic, adaptive reduction of myocardial contractile function in response to a reduction of myocardial ...

Cardiovascular Research, Heusch, Gerd, Ferrari, Roberto, Hearse, David J, Ruigrok, Tom J.C, Schulz, Rainer

Date : 01/12/1997

[...]with longer reperfusion ischemic preconditioning diminishes adverse left ventricular remodeling following infarction and improves long-term functional recovery in chronically instrumented ...

Cardiovascular Research, Schulz, Rainer, Cohen, Michael V, Behrends, Matthias, Downey, James M, Heusch, Gerd

Date : 01/11/2001 Item size : 857675 bytes

Remote ischemic conditioning is the systemic response to brief non-lethal ischemia/reperfusion in various tissues or organs which provides protection to a number of target tissues or organs over a ...

Cardiovascular Research, Heusch, Gerd

Date : 01/01/2017

Methods: In enflurane-anaesthetised swine the coronary blood flow through the left anterior descending coronary artery was decreased to reduce regional contractile function (microsonometry) by ...

Cardiovascular Research, Lüss, Hartmut, Boknıék, Peter, Heusch, Gerd, Müller, Frank Ulrich, Neumann, Joachim, Schmitz, Wilhelm, Schulz, Rainer

Date : 01/03/1998 Item size : 375729 bytes