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The cardioprotection achieved by IPw is completely abolished by blockade of bradykinin-B2-receptors. Since activation of bradykinin-B2-receptors subsequently activates cyclooxygenase, we now tested ...

Cardiovascular Research, Gres, Petra, Schulz, Rainer, Jansen, Johanna, Umschlag, Christian, Heusch, Gerd

Date : 15/08/2002 Item size : 265816 bytes

Abstract Objective: In isolated cardiac preparations of non-failing hearts from different species, including man, there is a positive forcefrequency relation which is reversed into a negative ...

Cardiovascular Research, Neumann, Till, Ravens, Ursula, Heusch, Gerd

Date : 01/02/1998 Item size : 334374 bytes

Acute myocardial infarction remains a significant health problem throughout the world, and for those patients surviving the immediate event, infarct size is the main determinant of further ...

Cardiovascular Research, Heusch, Gerd, Schulz, Rainer

Date : 01/10/2009 Item size : 290822 bytes

Ischaemic pre and postconditioning are powerful cardioprotective phenomena, in which infarct size is reduced by one or several short episodes of myocardial ischaemia with reperfusion preceding or ...

Cardiovascular Research, Boengler, Kerstin, Schulz, Rainer, Heusch, Gerd

Date : 15/07/2009 Item size : 675118 bytes

The potential for clinical application to benefit patients with a variety of pathological conditions has led to an expansion in our knowledge concerning the pathophysiology of ischemia-reperfusion ...

Cardiovascular Research, Yellon, Derek M, Baxter, Gary F, Garcia-Dorado, David, Heusch, Gerd, Sumeray, Mark S

Date : 01/01/1998 Item size : 548538 bytes

Ischaemic preconditioning, i.e. one or several brief cycles of myocardial ischaemia/reperfusion preceding a more sustained period of myocardial ischaemia with subsequent reperfusion, does not ...

Cardiovascular Research, Heusch, Gerd

Date : 01/11/2012 Item size : 141208 bytes

The signal transduction for protection from lethal reperfusion injury is still under intense debate.18 Yellon et al. have identified a concerted program of intracellular protein kinase activation ...

Cardiovascular Research, Heusch, Gerd

Date : 01/11/2009 Item size : 197316 bytes

Abstract Objectives: In human end-stage heart failure as well as in experimental animal models of heart failure, G-protein-coupled receptor kinase activity (GRK) is increased while β-adrenoceptor ...

Cardiovascular Research, Leineweber, Kirsten, Rohe, Patrick, Beilfuß, Anja, Wolf, Christina, Sporkmann, Heike, Bruck, Heike, Jakob, Heinz-Günther, Heusch, Gerd, Philipp, Thomas, Brodde, ...

Date : 01/06/2005 Item size : 256712 bytes

Methods and results In this study we verified the presence of mCx43 by a mass spectrometry-based proteomic approach in purified mitochondrial preparations from mouse myocardium and determined by ...

Cardiovascular Research, Miro-Casas, Elisabet, Ruiz-Meana, Marisol, Agullo, Esperanza, Stahlhofen, Sabine, Rodrı́guez-Sinovas, Antonio, Cabestrero, Alberto, Jorge, Inmaculada, Torre, Iratxe, ...

Date : 01/09/2009 Item size : 321019 bytes

In the context of coronary artery disease, myocardial hibernation was originally seen as a chronic, adaptive reduction of myocardial contractile function in response to a reduction of myocardial ...

Cardiovascular Research, Heusch, Gerd, Ferrari, Roberto, Hearse, David J, Ruigrok, Tom J.C, Schulz, Rainer

Date : 01/12/1997 Item size : 310638 bytes