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The cardioprotection achieved by IPw is completely abolished by blockade of bradykinin-B2-receptors. Since activation of bradykinin-B2-receptors subsequently activates cyclooxygenase, we now tested ...

Cardiovascular Research, Gres, Petra, Schulz, Rainer, Jansen, Johanna, Umschlag, Christian, Heusch, Gerd

Date : 15/08/2002 Item size : 264033 bytes

[...]the coronary microcirculation is also a target of both injury by myocardial ischaemia/reperfusion and protection from it. Starting with Jim Downey's original observation of a causal role for ...

Cardiovascular Research, Heusch, Gerd, Kleinbongard, Petra, Skyschally, Andreas, Levkau, Bodo, Schulz, Rainer, Erbel, Raimund

Date : 01/05/2012 Item size : 528789 bytes

The signal transduction for protection from lethal reperfusion injury is still under intense debate.18 Yellon et al. have identified a concerted program of intracellular protein kinase activation ...

Cardiovascular Research, Heusch, Gerd

Date : 01/11/2009 Item size : 197656 bytes

Abstract Objective: Short-term myocardial hibernation is characterized by an adaptation of contractile function to the reduced blood flow, the recovery of creatine phosphate content and lactate ...

Cardiovascular Research, Martin, Claus, Schulz, Rainer, Rose, Jochen, Heusch, Gerd

Date : 01/08/1998 Item size : 355727 bytes

In the context of coronary artery disease, myocardial hibernation was originally seen as a chronic, adaptive reduction of myocardial contractile function in response to a reduction of myocardial ...

Cardiovascular Research, Heusch, Gerd, Ferrari, Roberto, Hearse, David J, Ruigrok, Tom J.C, Schulz, Rainer

Date : 01/12/1997

Methods: In enflurane-anaesthetised swine the coronary blood flow through the left anterior descending coronary artery was decreased to reduce regional contractile function (microsonometry) by ...

Cardiovascular Research, Lüss, Hartmut, Boknıék, Peter, Heusch, Gerd, Müller, Frank Ulrich, Neumann, Joachim, Schmitz, Wilhelm, Schulz, Rainer

Date : 01/03/1998 Item size : 375729 bytes

Introduction Atherosclerotic plaque rupture, occurring either spontaneously or during coronary interventions, results in the release of atheromatous and/or thrombotic material into the coronary ...

Cardiovascular Research, Skyschally, Andreas, Schulz, Rainer, Gres, Petra, Konietzka, Ina, Martin, Claus, Haude, Michael, Erbel, Raimund, Heusch, Gerd

Date : 01/08/2004 Item size : 289509 bytes

Because of this, there is currently no effective therapy for protecting the heart against the detrimental effects of acute IRI in patients with CHD. According to the World Health Organisation (WHO), ...

Cardiovascular Research, Hausenloy, Derek J., Bøtker, Hans Erik, Condorelli, Gianluigi, Ferdinandy, Peter, Garcia-Dorado, David, Heusch, Gerd, Lecour, Sandrine, van Laake, Linda W., Madonna, ...

Date : 01/04/2013

Methods and results Anaesthetized pigs were subjected to 90 min left anterior descending coronary artery hypoperfusion and 120 min reperfusion. The activation of reperfusion injury salvage kinases ...

Cardiovascular Research, Musiolik, Judith, van Caster, Patrick, Skyschally, Andreas, Boengler, Kerstin, Gres, Petra, Schulz, Rainer, Heusch, Gerd

Date : 01/01/2010

The pivotal importance of myocardial perfusion for the maintenance of myocardial contractile function was already recognized some 60 years ago [1], but the functional and metabolic consequences of ...

Cardiovascular Research, Duncker, Dirk J, Schulz, Rainer, Ferrari, Roberto, Garcia-Dorado, David, Guarnieri, Carlo, Heusch, Gerd, Verdouw, Pieter D

Date : 01/06/1998 Item size : 591389 bytes