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Pre-treatment with trimetazidine increases sarcolemmal mechanical resistance in reoxygenated myocytes

Cardiovascular Research, Ruiz-Meana, Marisol, Garcia-Dorado, David, Juliá, Margarita, González, Miguel A., Inserte, Javier, Soler-Soler, J.

Date : 01/09/1996

Methods: Twenty-six isolated rat hearts and 23 in situ porcine hearts were submitted to no-flow ischemia followed by reperfusion, with or without pre-treatment with cariporide (7 μM in rats and 3 ...

Cardiovascular Research, Rodríguez-Sinovas, Antonio, García-Dorado, David, Padilla, Ferran, Inserte, Javier, Barrabés, José Antonio, Ruiz-Meana, Marisol, Agulló, Luis, Soler-Soler, ...

Date : 01/04/2003

Methods: Calpain activity and degradation of different structural proteins were studied along with the extent of necrosis in isolated rat hearts submitted to 60 min of ischemia and 30 min of ...

Cardiovascular Research, Inserte, Javier, Garcia-Dorado, David, Ruiz-Meana, Marisol, Agulló, Luis, Pina, Pilar, Soler-Soler, Jordi

Date : 01/10/2004 Item size : 295461 bytes

Intravenous administration of the natriuretic peptide urodilatin at low doses during coronary reperfusion limits infarct size in anesthetized pigs The dose of intravenous URO necessary to obtain the ...

Cardiovascular Research, Padilla, Ferran, Garcia-Dorado, David, Agulló, Luis, Barrabés, José A, Inserte, Javier, Escalona, Noelia, Meyer, Markus, Mirabet, Maribel, Pina, Pilar, Soler-Soler, ...

Date : 15/08/2001 Item size : 299203 bytes

The original description Twenty-five years is a long time in biomedical research, and most of today's cardiovascular scientists were at university or high school when ischaemic preconditioning was ...

Cardiovascular Research, Garcia-Dorado, David, Barba, Ignasi, Inserte, Javier

Date : 01/08/2011 Item size : 188883 bytes

[...]the so-called Ca2+ paradox (hypercontracture and death of cardiomyocytes occurring upon restoration of Ca2+ after a Ca2+-free perfusion period) was meant to be a first cellular model of ...

Cardiovascular Research, Garcia-Dorado, David, Ruiz-Meana, Marisol, Inserte, Javier, Rodriguez-Sinovas, Antonio, Piper, Hans Michael

Date : 01/05/2012 Item size : 742256 bytes

Research on the mechanisms leading to sarcolemmal rupture and necrosis during initial reperfusion identified several promising pharmacological targets directed either to correct the alterations in ...

Cardiovascular Research, Inserte, Javier, Barrabés, José A., Hernando, Víctor, Garcia-Dorado, David

Date : 15/07/2009 Item size : 459107 bytes

Methods Intracellular Na+ concentration ([Na+]i) measured using 23Na-magnetic resonance spectroscopy, Na+/K+-ATPase activity, detachment of Na+/K+-ATPase α subunits from the membrane cytoskeleton, ...

Cardiovascular Research, Inserte, Javier, Garcia-Dorado, David, Hernando, Victor, Barba, Ignasi, Soler-Soler, Jordi

Date : 01/05/2006 Item size : 331955 bytes

Lowering perfusion flow to 50% during reperfusion cycles or shortening the cycles (12 cycles of 5 s ischemiareperfusion) resulted in a further delay in pHi recovery (4.1 ± 0.2 and 3.5 ± 0.3 ...

Cardiovascular Research, Inserte, Javier, Barba, Ignasi, Hernando, Víctor, Garcia-Dorado, David

Date : 01/01/2009 Item size : 250190 bytes

Methods and results The effect of acidic perfusion on reperfusion injury was studied in isolated rat hearts submitted to 40 min of ischaemia and 30 min of reperfusion, and its effect on the ...

Cardiovascular Research, Inserte, Javier, Barba, Ignasi, Hernando, Víctor, Abellán, Arancha, Ruiz-Meana, Marisol, Rodríguez-Sinovas, Antonio, Garcia-Dorado, David

Date : 01/03/2008 Item size : 272503 bytes