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Methods and results LA-remodelling was studied in dogs with heart failure (HF) induced by ventricular tachypacing (VTP, 240 bpm), and in mice with left-ventricular (LV) dysfunction due to myocardial ...

Cardiovascular Research, Chen, Yu, Surinkaew, Sirirat, Naud, Patrice, Qi, Xiao-Yan, Gillis, Marc-Antoine, Shi, Yan-Fen, Tardif, Jean-Claude, Dobrev, Dobromir, Nattel, Stanley

Date : 01/03/2017 Item size : 142189 bytes

In disease states, fibroblast production of increased quantities of ECM proteins leads to tissue fibrosis, which can impair both mechanical and electrical function of the heart, contributing to heart ...

Cardiovascular Research, Yue, Lixia, Xie, Jia, Nattel, Stanley

Date : 01/03/2011 Item size : 492471 bytes

Furthermore, studies in humans suggest a protective role for HSPs against progression from paroxysmal AF to chronic, persistent AF. [...]manipulation of the HSP system may offer novel therapeutic ...

Cardiovascular Research, Brundel, Bianca J.J.M., Ke, Lei, Dijkhuis, Anne-Jan, Qi, XiaoYan, Shiroshita-Takeshita, Akiko, Nattel, Stanley, Henning, Robert H., Kampinga, Harm H.

Date : 01/06/2008

Abstract Aims Although atrial tachycardia (AT) remodelling promotes agonist-independent, constitutively active, acetylcholine-regulated K+-current (IK,ACh) that increases susceptibility to atrial ...

Cardiovascular Research, Voigt, Niels, Maguy, Ange, Yeh, Yung-Hsin, Qi, Xiaoyan, Ravens, Ursula, Dobrev, Dobromir, Nattel, Stanley

Date : 01/01/2008 Item size : 251668 bytes

Department of Medicine, Montreal Heart Institute and University of Montreal, 5000 Belanger Street East, Montreal, Quebec HIT 1C3, Canada: B Fermini, S Nattel; Departments of Pharmacology and ...

Cardiovascular Research, Wang, Zhiguo, Fermini, Bernard, Nattel, Stanley

Date : 01/10/1994 Item size : 99625 bytes

Atrial fibrillation (AF) is the most common sustained clinical arrhythmia, and is an increasing problem in terms of prevalence, complications, and health costs.1 The options for treating AF are ...

Cardiovascular Research, Nattel, Stanley

Date : 01/06/2016 Item size : 96539 bytes

Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with substantial cardiovascular morbidity and mortality, with stroke being the most critical complication.1 Present drugs ...

Cardiovascular Research, Dobrev, Dobromir, Nattel, Stanley

Date : 01/03/2011 Item size : 158514 bytes

Abstract Background: Loss of rate-dependent action potential (AP) duration (APD) adaptation is a characteristic feature of atrial tachycardia-induced remodeling (ATR). Unaltered Ca2+-handling ...

Cardiovascular Research, Kneller, James, Sun, Hui, Leblanc, Normand, Nattel, Stanley

Date : 01/05/2002

Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure Abstract Background: Congestive heart failure (CHF) is a common cause of atrial ...

Cardiovascular Research, Shiroshita-Takeshita, Akiko, Brundel, Bianca J.J.M., Burstein, Brett, Leung, Tack-Ki, Mitamura, Hideo, Ogawa, Satoshi, Nattel, Stanley

Date : 01/04/2007

Methods: Whole-cell patch clamp techniques were applied to assess the effects of 293B on isolated myocytes at 36°C. Results: Delayed rectifier current (IK) elicited by pulses to +60 mV from a ...

Cardiovascular Research, Bosch, Ralph F., Gaspo, Rania, Busch, Andreas E., Lang, Hans J., Li, Gui-Rong, Nattel, Stanley

Date : 01/05/1998