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Pre-treatment with trimetazidine increases sarcolemmal mechanical resistance in reoxygenated myocytes

Cardiovascular Research, Ruiz-Meana, Marisol, Garcia-Dorado, David, Juliá, Margarita, González, Miguel A., Inserte, Javier, Soler-Soler, J.

Date : 01/09/1996

Abstract Gap junction-mediated intercellular communication (GJMIC) has been known for a long time to be essential in propagation of electrical impulse in the heart, and the contribution of altered ...

Cardiovascular Research, Garcı́a-Dorado, David, Rodrı́guez-Sinovas, Antonio, Ruiz-Meana, Marisol

Date : 15/02/2004 Item size : 576029 bytes

Methods: Twenty-six isolated rat hearts and 23 in situ porcine hearts were submitted to no-flow ischemia followed by reperfusion, with or without pre-treatment with cariporide (7 μM in rats and 3 ...

Cardiovascular Research, Rodríguez-Sinovas, Antonio, García-Dorado, David, Padilla, Ferran, Inserte, Javier, Barrabés, José Antonio, Ruiz-Meana, Marisol, Agulló, Luis, Soler-Soler, ...

Date : 01/04/2003

Remarkably, as the ΔΨm dissipates, i.e. under hypoxic conditions or when H+ influx follows an alternative route not coupled to energy production, mitochondria can act as ATP consumers by ...

Cardiovascular Research, Ruiz-Meana, Marisol, Fernandez-Sanz, Celia, Garcia-Dorado, David

Date : 01/10/2010 Item size : 610748 bytes

Despite a significant decrease in the numbers of animals used in biomedical research and testing in the last two decades, in part due to more restrictive policies and development of alternative ...

Cardiovascular Research, Ruiz-Meana, Marisol, Martinson, Elizabeth A., Garcia-Dorado, David, Piper, Hans Michael

Date : 01/01/2012 Item size : 135630 bytes

Since its first description 25 years ago,1 ischaemic preconditioning has become one of the most studied protective interventions in the cardiovascular field, in part due to its universality (it is ...

Cardiovascular Research, Ruiz-Meana, Marisol

Date : 01/11/2012 Item size : 186987 bytes

Recovery from mechanical fragility was studied by exposing cells to hypotonic buffer 20 or 40 min after restoration of metabolic activity, in either presence or absence of 2,3-butanedione ...

Cardiovascular Research, Ruiz-Meana, Marisol, García-Dorado, David, González, Miguel A., Barrabés, José A., Soler-Soler, J.

Date : 01/07/1995 Item size : 104683 bytes

Introduction Remote ischaemic conditioning (RIC), a manoeuvre consisting of short episodes of ischaemiareperfusion applied in one vascular bed or tissue, has been shown to protect the heart against a ...

Cardiovascular Research, José Alburquerque-Béjar, Juan, Barba, Ignasi, Valls-Lacalle, Laura, Ruiz-Meana, Marisol, Pecoraro, Michela, Rodríguez-Sinovas, Antonio, García-Dorado, David

Date : 01/01/2017

Methods: Calpain activity and degradation of different structural proteins were studied along with the extent of necrosis in isolated rat hearts submitted to 60 min of ischemia and 30 min of ...

Cardiovascular Research, Inserte, Javier, Garcia-Dorado, David, Ruiz-Meana, Marisol, Agulló, Luis, Pina, Pilar, Soler-Soler, Jordi

Date : 01/10/2004 Item size : 295461 bytes

[...]the so-called Ca2+ paradox (hypercontracture and death of cardiomyocytes occurring upon restoration of Ca2+ after a Ca2+-free perfusion period) was meant to be a first cellular model of ...

Cardiovascular Research, Garcia-Dorado, David, Ruiz-Meana, Marisol, Inserte, Javier, Rodriguez-Sinovas, Antonio, Piper, Hans Michael

Date : 01/05/2012 Item size : 742256 bytes