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Not only do disease states affect the determinants of cardiac electrical function in profound ways, but we now recognise that cardiac arrhythmias can themselves produce profound changes in the ...

Cardiovascular Research, Editorial, Stanley Nattel, Dan M. Roden, Denis Escande

Date : 01/05/1999 Item size : 177552 bytes

Arrhythmogenic right ventricular dysplasia type 1 and mutations in transforming growth factor β3 gene regulatory regions: a breakthrough? Arrhythmogenic right ventricular dysplasia (ARVD) is the ...

Cardiovascular Research, Editorial, Stanley Nattel, Jean-Jacques Schott

Date : 01/02/2005 Item size : 199393 bytes

In disease states, fibroblast production of increased quantities of ECM proteins leads to tissue fibrosis, which can impair both mechanical and electrical function of the heart, contributing to heart ...

Cardiovascular Research, REVIEWS: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Lixia Yue, Jia Xie, Stanley Nattel

Date : 01/03/2011 Item size : 519835 bytes

Abstract Objectives: Atrial tachycardia-induced remodeling (ATR) and ventricular tachypacing-induced heart failure (HF) create experimental substrates for atrial fibrillation (AF), and both have been ...

Cardiovascular Research, Original Article, Yanfen Shi, Anique Ducharme, Danshi Li, Rania Gaspo, Stanley Nattel, Jean-Claude Tardif

Date : 01/11/2001 Item size : 282722 bytes

Here, we assessed the differential expression of Kv currents between atrial and ventricular fibroblasts from control dogs and dogs with an atrial arrhythmogenic substrate caused by congestive heart ...

Cardiovascular Research, Ion channels and arrhythmias, Chia-Tung Wu, Xiao-Yan Qi, Hai Huang, Patrice Naud, Kristin Dawson, Yung-Hsin Yeh, Masahide Harada, Chi-Tai Kuo, Stanley Nattel

Date : 01/06/2014 Item size : 319683 bytes

Recently, a single nucleotide polymorphism (SNP, A/G) at position 112 in the KCNE1 gene, resulting in a glycine/serine amino acid substitution at position 38 of the minK peptide, was associated with ...

Cardiovascular Research, Original Article, Joachim R. Ehrlich, Stephen Zicha, Pierre Coutu, Terence E. Hébert, Stanley Nattel

Date : 15/08/2005 Item size : 273814 bytes

Abstract Objectives: Canine atrial cardiomyocytes display a constitutively active, acetylcholine-regulated, time-dependent K+ current (IKH) that contributes to atrial repolarization and atrial ...

Cardiovascular Research, Original Article, Yung-Hsin Yeh, Joachim R. Ehrlich, Xiaoyan Qi, Terence E. Hébert, Denis Chartier, Stanley Nattel

Date : 01/06/2007 Item size : 332581 bytes

Introduction Atrial fibrillation (AF), the most common sustained arrhythmia, is characterized by atrial electrical, contractile, and structural remodelling.1,2 Structural remodelling includes ...

Cardiovascular Research, Original Article, Yung-Hsin Yeh, Chi-Tai Kuo, Ting-Hsiang Chan, Gwo-Jyh Chang, Xiao-Yan Qi, FengChun Tsai, Stanley Nattel, Wei-Jan Chen

Date : 01/07/2011 Item size : 296099 bytes

The identification of the molecular structure of many ion channels involved in cardiac excitability and their functional correlation with native ionic currents have made it possible to study the ...

Cardiovascular Research, Review, Ralph F Bosch, Stanley Nattel

Date : 01/05/2002 Item size : 503601 bytes

Results: Verapamil caused AF promotion in six dogs, increasing mean duration of AF induced by burst pacing, from 8±4 s (mean±S.E.) to 95±39 s (P<0.01 vs. control) at a loading dose of 0.1 ...

Cardiovascular Research, Original Article, Agnès Bénardeau, Samir Fareh, Stanley Nattel

Date : 01/04/2001 Item size : 252007 bytes