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[...]GPA prolonged atrial refractory period and decreased AF vulnerability (75 ± 8 to 30 ± 10%, P< 0.05), AF duration (617 ± 246 to 39 ± 23 s, **P< 0.01), and DF (11.4 ± 0.6 to 8.6 ...

Cardiovascular Research, ORIGINAL ARTICLES: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Kunihiro Nishida, Ange Maguy, Masao Sakabe, Philippe Comtois, Hiroshi Inoue, Stanley Nattel

Date : 01/03/2011

Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with substantial cardiovascular morbidity and mortality, with stroke being the most critical complication.1 Present drugs ...

Cardiovascular Research, EDITORIAL: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Dobromir Dobrev, Stanley Nattel

Date : 01/03/2011

In cardiac disease states such as heart failure and atrial fibrillation (AF), changes in ion channel properties appear as part of an adaptive response to maintain function in the face of ...

Cardiovascular Research, Review, Georghia Michael, Ling Xiao, Xiao-Yan Qi, Dobromir Dobrev, Stanley Nattel

Date : 15/02/2009

No change in ERP or AF duration occurred at 160 bpm. Because of the limited effects of 200 bpm ATP on AF duration despite significant effects on ERP, we tested 200 bpm ATP effects in the presence of ...

Cardiovascular Research, Original Article, Akiko Shiroshita-Takeshita, Hideo Mitamura, Satoshi Ogawa, Stanley Nattel

Date : 01/01/2009

Abstract Aims Impaired repolarization in cardiac myocytes can lead to long QT syndrome (LQTS), with delayed repolarization and increased susceptibility to Torsades de Pointes (TdP) ...

Cardiovascular Research, Original Article, Thomas G. Diness, Yung-Hsin Yeh, Xiao Yan Qi, Denis Chartier, Yukiomi Tsuji, Rie S. Hansen, Soren-Peter Olesen, Morten Grunnet, Stanley Nattel

Date : 01/07/2008

Furthermore, studies in humans suggest a protective role for HSPs against progression from paroxysmal AF to chronic, persistent AF. [...]manipulation of the HSP system may offer novel therapeutic ...

Cardiovascular Research, Review, Bianca J.J.M. Brundel, Lei Ke, Anne-Jan Dijkhuis, XiaoYan Qi, Akiko Shiroshita-Takeshita, Stanley Nattel, Robert H. Henning, Harm H. Kampinga

Date : 01/06/2008 Item size : 448399 bytes

Introduction Atrial fibrillation (AF) is a common cardiac arrhythmia associated with increased cardiovascular morbidity and mortality.13 Conventional anti-arrhythmic drugs often fail to provide ...

Cardiovascular Research, Original Article, Masao Sakabe, Akiko Shiroshita-Takeshita, Ange Maguy, Bianca J.J.M. Brundel, Akira Fujiki, Hiroshi Inoue, Stanley Nattel

Date : 01/04/2008

Abstract Aims Although atrial tachycardia (AT) remodelling promotes agonist-independent, constitutively active, acetylcholine-regulated K+-current (IK,ACh) that increases susceptibility to atrial ...

Cardiovascular Research, RAPID COMMUNICATION, Niels Voigt, Ange Maguy, Yung-Hsin Yeh, Xiaoyan Qi, Ursula Ravens, Dobromir Dobrev, Stanley Nattel

Date : 01/01/2008

Ventricular dysfunction due to a rapid response to AF can cause structural remodeling, but whether AF itself directly promotes atrial fibrosis is controversial. 2 Methods 2.1 Cardiomyocyte culture ...

Cardiovascular Research, Original Article, Brett Burstein, Xiao-Yan Qi, Yung-Hsin Yeh, Angelino Calderone, Stanley Nattel

Date : 01/12/2007

Abstract Objectives: Canine atrial cardiomyocytes display a constitutively active, acetylcholine-regulated, time-dependent K+ current (IKH) that contributes to atrial repolarization and atrial ...

Cardiovascular Research, Original Article, Yung-Hsin Yeh, Joachim R. Ehrlich, Xiaoyan Qi, Terence E. Hébert, Denis Chartier, Stanley Nattel

Date : 01/06/2007 Item size : 332581 bytes