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Ehjcardiovascrec

[...]GPA prolonged atrial refractory period and decreased AF vulnerability (75 ± 8 to 30 ± 10%, P< 0.05), AF duration (617 ± 246 to 39 ± 23 s, **P< 0.01), and DF (11.4 ± 0.6 to 8.6 ...

Cardiovascular Research, ORIGINAL ARTICLES: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Kunihiro Nishida, Ange Maguy, Masao Sakabe, Philippe Comtois, Hiroshi Inoue, Stanley Nattel

Date : 01/03/2011
Ehjcardiovascrec

Methods: The whole-cell voltage-clamp technique was used to measure INa during a variety of depolarizing pulse protocols in isolated human atrial myocytes, in the presence and absence of ...

Cardiovascular Research, Original Article, Elias Bou-Abboud, Stanley Nattel

Date : 01/05/1998
Ehjcardiovascrec

Introduction Atrial fibrillation (AF) is a common cardiac arrhythmia associated with increased cardiovascular morbidity and mortality.13 Conventional anti-arrhythmic drugs often fail to provide ...

Cardiovascular Research, Original Article, Masao Sakabe, Akiko Shiroshita-Takeshita, Ange Maguy, Bianca J.J.M. Brundel, Akira Fujiki, Hiroshi Inoue, Stanley Nattel

Date : 01/04/2008
Ehjcardiovascrec

Varying minK expression is important in disease-related remodeling and species-dependent expression. The core promoter conferred cardiomyocyte-preferential expression, with an activity in NRMs ...

Cardiovascular Research, Original Article, Zenab Mustapha, Li Pang, Stanley Nattel

Date : 01/01/2007
Ehjcardiovascrec

Abstract Aims Impaired repolarization in cardiac myocytes can lead to long QT syndrome (LQTS), with delayed repolarization and increased susceptibility to Torsades de Pointes (TdP) ...

Cardiovascular Research, Original Article, Thomas G. Diness, Yung-Hsin Yeh, Xiao Yan Qi, Denis Chartier, Yukiomi Tsuji, Rie S. Hansen, Soren-Peter Olesen, Morten Grunnet, Stanley Nattel

Date : 01/07/2008
Ehjcardiovascrec

Atrial cellular arrhythmia mechanisms have not been defined in congenital LQTS. [...]we studied atrial cardiomyocyte electrophysiology in mice with an LQTS3 SCN5A inactivation-impairing mutation ...

Cardiovascular Research, Original Article, Marc D. Lemoine, James Elber Duverger, Patrice Naud, Denis Chartier, Xiao Yan Qi, Philippe Comtois, Larissa Fabritz, Paulus Kirchhof, Stanley Nattel

Date : 01/10/2011
Ehjcardiovascrec

Results: Mean duration of burst-pacing induced AF was similar in placebo (567±203 s) and diltiazem-treated (963±280 s, P = NS) animals, but was much less in mibefradil-treated dogs (3.6±0.9 ...

Cardiovascular Research, Original Article, Samir Fareh, Agnès Bénardeau, Stanley Nattel

Date : 01/03/2001
Ehjcardiovascrec

Abstract Background: There is evidence suggesting involvement of oxidative stress, inflammation, and calcineurin/nuclear factor of activated T cell pathways in atrial fibrillation. Dogs were ...

Cardiovascular Research, Original Article, Akiko Shiroshita-Takeshita, Bianca J.J.M. Brundel, Joel Lavoie, Stanley Nattel

Date : 01/03/2006
Ehjcardiovascrec

Abstract Aims Although atrial tachycardia (AT) remodelling promotes agonist-independent, constitutively active, acetylcholine-regulated K+-current (IK,ACh) that increases susceptibility to atrial ...

Cardiovascular Research, RAPID COMMUNICATION, Niels Voigt, Ange Maguy, Yung-Hsin Yeh, Xiaoyan Qi, Ursula Ravens, Dobromir Dobrev, Stanley Nattel

Date : 01/01/2008
Ehjcardiovascrec

Figure 6 Mean ± SEM Cav3.1 and Cav3.2-mRNA expression in left atrial (LA) and LV tissues at baseline and 4 weeks post-MI, for Cav3.1+/+ and Cav3.1 (A and B) and Cav3.2+/+ and Cav3.2 (C and D) ...

Cardiovascular Research, Original Article, Khai Le Quang, Patrice Naud, Xiao-Yan Qi, Francine Duval, Yan-Fen Shi, Marc-Antoine Gillis, Philippe Comtois, Jean-Claude Tardif, Danshi Li, Paul C. ...

Date : 01/08/2011