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Methods: Standard whole-cell patch clamp techniques were used to study the effects of multiple concentrations of each drug. The magnitude of voltage-dependent block was directly related to the ...

Cardiovascular Research, Original Article, Lixia Yue, Jian Lin Feng, Zhiguo Wang, Stanley Nattel

Date : 01/04/2000

Methods: Whole-cell patch clamp techniques were applied to assess the effects of 293B on isolated myocytes at 36°C. Results: Delayed rectifier current (IK) elicited by pulses to +60 mV from a ...

Cardiovascular Research, Original Article, Ralph F. Bosch, Rania Gaspo, Andreas E. Busch, Hans J. Lang, Gui-Rong Li, Stanley Nattel

Date : 01/05/1998

Ionic targets for drug therapy and atrial fibrillation-induced electrical remodeling: insights from a mathematical model Objectives: Using a mathematical model of the human atrial action potential ...

Cardiovascular Research, Original Article, Marc Courtemanche, Rafael J Ramirez, Stanley Nattel

Date : 01/05/1999

Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure Abstract Background: Congestive heart failure (CHF) is a common cause of atrial ...

Cardiovascular Research, Original Article, Akiko Shiroshita-Takeshita, Bianca J.J.M. Brundel, Brett Burstein, Tack-Ki Leung, Hideo Mitamura, Satoshi Ogawa, Stanley Nattel

Date : 01/04/2007

After initial dismissal of a functional role for SK channels in the heart,1 a series of elegant studies from the Chiamvimonvat laboratory rekindled interest,2,3 as did subsequent work suggesting that ...

Cardiovascular Research, Editorial, Stanley Nattel, Xiao Yan Qi

Date : 01/02/2014

Much remains to be learned about this area of potentially enormous importance to cardiac function in health and disease. Introduction Ion channels play a critical role in shaping the cardiac action ...

Cardiovascular Research, Review in Review Focus Series on Caveolae in Cardiovascular Signaling, Ange Maguy, Terence E. Hebert, Stanley Nattel

Date : 01/03/2006

Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with substantial cardiovascular morbidity and mortality, with stroke being the most critical complication.1 Present drugs ...

Cardiovascular Research, EDITORIAL: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Dobromir Dobrev, Stanley Nattel

Date : 01/03/2011

Background: Azimilide, a new class III drug, was initially believed to be a highly selective blocker of the slow delayed rectifier (IKs), but recent studies suggest that azimilide potently blocks ...

Cardiovascular Research, Original Article, Stanley Nattel, Lili Liu, Dalie St-Georges

Date : 01/03/1998

No change in ERP or AF duration occurred at 160 bpm. Because of the limited effects of 200 bpm ATP on AF duration despite significant effects on ERP, we tested 200 bpm ATP effects in the presence of ...

Cardiovascular Research, Original Article, Akiko Shiroshita-Takeshita, Hideo Mitamura, Satoshi Ogawa, Stanley Nattel

Date : 01/01/2009

Abstract Objectives: This study evaluated the in vivo electrophysiological effects of a highly selective slow delayed-rectifier K+-current blocker, HMR 1556, to gain insights into the consequences of ...

Cardiovascular Research, Original Article, Hideko Nakashima, Uwe Gerlach, Dietmar Schmidt, Stanley Nattel

Date : 01/03/2004