Abstract Background: We have shown that rapid atrial activation, as occurs during atrial fibrillation (AF), reduces L-type Ca2+ current (ICa) and that this is the principal mechanism of the action ...

Cardiovascular Research, Original Article, Rania Gaspo, Hui Sun, Samir Fareh, Mirie Levi, Lixia Yue, Bruce G. Allen, Terence E. Hebert, Stanley Nattel

Results: Verapamil caused AF promotion in six dogs, increasing mean duration of AF induced by burst pacing, from 8±4 s (mean±S.E.) to 95±39 s (P<0.01 vs. control) at a loading dose of 0.1 ...

Cardiovascular Research, Original Article, Agnès Bénardeau, Samir Fareh, Stanley Nattel

Results: Mean duration of burst-pacing induced AF was similar in placebo (567±203 s) and diltiazem-treated (963±280 s, P = NS) animals, but was much less in mibefradil-treated dogs (3.6±0.9 ...

Cardiovascular Research, Original Article, Samir Fareh, Agnès Bénardeau, Stanley Nattel