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Abstract Background: We have shown that rapid atrial activation, as occurs during atrial fibrillation (AF), reduces L-type Ca2+ current (ICa) and that this is the principal mechanism of the action ...

Cardiovascular Research, Original Article, Rania Gaspo, Hui Sun, Samir Fareh, Mirie Levi, Lixia Yue, Bruce G. Allen, Terence E. Hebert, Stanley Nattel

Date : 01/05/1999 Item size : 258753 bytes

Results: Mean duration of burst-pacing induced AF was similar in placebo (567±203 s) and diltiazem-treated (963±280 s, P = NS) animals, but was much less in mibefradil-treated dogs (3.6±0.9 ...

Cardiovascular Research, Original Article, Samir Fareh, Agnès Bénardeau, Stanley Nattel

Date : 01/03/2001

Abstract One of the most exciting developments in our understanding of atrial fibrillation (AF) over the last several years has been the recognition that AF itself modifies atrial electrical ...

Cardiovascular Research, Review, Stanley Nattel

Date : 01/05/1999

Methods: Dogs were subjected to atrial-tachypacing (400 bpm) for 7 days during treatment with 240 mg/day (standard clinical dose) of the NHE1 inhibitor cariporide (CariL, n=6), 1000 mg/day cariporide ...

Cardiovascular Research, Original Article, Kaori Shinagawa, Hideo Mitamura, Satoshi Ogawa, Stanley Nattel

Date : 01/05/2002

Background: Azimilide, a new class III drug, was initially believed to be a highly selective blocker of the slow delayed rectifier (IKs), but recent studies suggest that azimilide potently blocks ...

Cardiovascular Research, Original Article, Stanley Nattel, Lili Liu, Dalie St-Georges

Date : 01/03/1998