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In order for improved antiarrhythmic drug therapy to be developed, it is essential to understand the fundamental mechanisms that cause proarrhythmic reactions to antiarrhythmic ...

Cardiovascular Research, Review, Stanley Nattel

Date : 01/03/1998 Item size : 434656 bytes

Introduction Atrial fibrillation (AF) is a common cardiac arrhythmia associated with increased cardiovascular morbidity and mortality.13 Conventional anti-arrhythmic drugs often fail to provide ...

Cardiovascular Research, Original Article, Masao Sakabe, Akiko Shiroshita-Takeshita, Ange Maguy, Bianca J.J.M. Brundel, Akira Fujiki, Hiroshi Inoue, Stanley Nattel

Date : 01/04/2008

Abstract Objective: Acute atrial ischemia produces a substrate for atrial fibrillation (AF) maintenance, but the response of this substrate to antiarrhythmic-drugs has not been defined. Isolated ...

Cardiovascular Research, Original Article, Lena Rivard, Hani Sinno, Akiko Shiroshita-Takeshita, Gernot Schram, Tack-Ki Leung, Stanley Nattel

Date : 01/04/2007

Methods: Whole-cell patch clamp techniques were applied to assess the effects of 293B on isolated myocytes at 36°C. Results: Delayed rectifier current (IK) elicited by pulses to +60 mV from a ...

Cardiovascular Research, Original Article, Ralph F. Bosch, Rania Gaspo, Andreas E. Busch, Hans J. Lang, Gui-Rong Li, Stanley Nattel

Date : 01/05/1998