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Ehjcardiovascrec

Abstract Background: We have shown that rapid atrial activation, as occurs during atrial fibrillation (AF), reduces L-type Ca2+ current (ICa) and that this is the principal mechanism of the action ...

Cardiovascular Research, Original Article, Rania Gaspo, Hui Sun, Samir Fareh, Mirie Levi, Lixia Yue, Bruce G. Allen, Terence E. Hebert, Stanley Nattel

Date : 01/05/1999 Item size : 258753 bytes
Ehjcardiovascrec

Results: Verapamil caused AF promotion in six dogs, increasing mean duration of AF induced by burst pacing, from 8±4 s (mean±S.E.) to 95±39 s (P<0.01 vs. control) at a loading dose of 0.1 ...

Cardiovascular Research, Original Article, Agnès Bénardeau, Samir Fareh, Stanley Nattel

Date : 01/04/2001 Item size : 252007 bytes
Ehjcardiovascrec

Background: Azimilide, a new class III drug, was initially believed to be a highly selective blocker of the slow delayed rectifier (IKs), but recent studies suggest that azimilide potently blocks ...

Cardiovascular Research, Original Article, Stanley Nattel, Lili Liu, Dalie St-Georges

Date : 01/03/1998
Ehjcardiovascrec

Abstract Objectives: This study evaluated the in vivo electrophysiological effects of a highly selective slow delayed-rectifier K+-current blocker, HMR 1556, to gain insights into the consequences of ...

Cardiovascular Research, Original Article, Hideko Nakashima, Uwe Gerlach, Dietmar Schmidt, Stanley Nattel

Date : 01/03/2004
Ehjcardiovascrec

KeywordsAntiarrhythmic agentsArrhythmia (mechanisms)Supraventricular arrhythmiaTime for primary review 34 days. 1 Introduction Atrial fibrillation (AF) is the most common sustained arrhythmia in ...

Cardiovascular Research, Original Article, Katayoun Derakhchan, Christine Villemaire, Mario Talajic, Stanley Nattel

Date : 01/04/2001
Ehjcardiovascrec

Little is known about the expression of corresponding hyperpolarization-activated cyclic nucleotide-gated (HCN) channel subunits in normal hearts and HCN remodeling by diseases, like congestive heart ...

Cardiovascular Research, Original Article, Stephen Zicha, María Fernández-Velasco, Giuseppe Lonardo, Nathalie L'Heureux, Stanley Nattel

Date : 01/06/2005