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Abstract Objectives: Atrial tachycardia-induced remodeling (ATR) and ventricular tachypacing-induced heart failure (HF) create experimental substrates for atrial fibrillation (AF), and both have been ...

Cardiovascular Research, Original Article, Yanfen Shi, Anique Ducharme, Danshi Li, Rania Gaspo, Stanley Nattel, Jean-Claude Tardif

Date : 01/11/2001 Item size : 282722 bytes

Results: Verapamil caused AF promotion in six dogs, increasing mean duration of AF induced by burst pacing, from 8±4 s (mean±S.E.) to 95±39 s (P<0.01 vs. control) at a loading dose of 0.1 ...

Cardiovascular Research, Original Article, Agnès Bénardeau, Samir Fareh, Stanley Nattel

Date : 01/04/2001 Item size : 252007 bytes

[...]GPA prolonged atrial refractory period and decreased AF vulnerability (75 ± 8 to 30 ± 10%, P< 0.05), AF duration (617 ± 246 to 39 ± 23 s, **P< 0.01), and DF (11.4 ± 0.6 to 8.6 ...

Cardiovascular Research, ORIGINAL ARTICLES: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Kunihiro Nishida, Ange Maguy, Masao Sakabe, Philippe Comtois, Hiroshi Inoue, Stanley Nattel

Date : 01/03/2011

Results: Mean duration of burst-pacing induced AF was similar in placebo (567±203 s) and diltiazem-treated (963±280 s, P = NS) animals, but was much less in mibefradil-treated dogs (3.6±0.9 ...

Cardiovascular Research, Original Article, Samir Fareh, Agnès Bénardeau, Stanley Nattel

Date : 01/03/2001

Abstract Background: There is evidence suggesting involvement of oxidative stress, inflammation, and calcineurin/nuclear factor of activated T cell pathways in atrial fibrillation. Dogs were ...

Cardiovascular Research, Original Article, Akiko Shiroshita-Takeshita, Bianca J.J.M. Brundel, Joel Lavoie, Stanley Nattel

Date : 01/03/2006

Abstract Aims Although atrial tachycardia (AT) remodelling promotes agonist-independent, constitutively active, acetylcholine-regulated K+-current (IK,ACh) that increases susceptibility to atrial ...

Cardiovascular Research, RAPID COMMUNICATION, Niels Voigt, Ange Maguy, Yung-Hsin Yeh, Xiaoyan Qi, Ursula Ravens, Dobromir Dobrev, Stanley Nattel

Date : 01/01/2008

Methods: Dogs were subjected to atrial-tachypacing (400 bpm) for 7 days during treatment with 240 mg/day (standard clinical dose) of the NHE1 inhibitor cariporide (CariL, n=6), 1000 mg/day cariporide ...

Cardiovascular Research, Original Article, Kaori Shinagawa, Hideo Mitamura, Satoshi Ogawa, Stanley Nattel

Date : 01/05/2002

Ionic targets for drug therapy and atrial fibrillation-induced electrical remodeling: insights from a mathematical model Objectives: Using a mathematical model of the human atrial action potential ...

Cardiovascular Research, Original Article, Marc Courtemanche, Rafael J Ramirez, Stanley Nattel

Date : 01/05/1999

No change in ERP or AF duration occurred at 160 bpm. Because of the limited effects of 200 bpm ATP on AF duration despite significant effects on ERP, we tested 200 bpm ATP effects in the presence of ...

Cardiovascular Research, Original Article, Akiko Shiroshita-Takeshita, Hideo Mitamura, Satoshi Ogawa, Stanley Nattel

Date : 01/01/2009