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1 Introduction When surveying the literature with the intention of evaluating to which extent studies on animal models have contributed to the understanding of arrhythmia mechanisms in patients and ...

Cardiovascular Research, Review, Michiel J. Janse, Tobias Opthof, André G. Kléber

Date : 01/07/1998 Item size : 562183 bytes

Abstract L-type Ca2+ channels are predominantly regulated by β-adrenergic stimulation, enhancing L-type Ca2+ current by increasing the mean channel open time and/or the opening probability of ...

Cardiovascular Research, Review, Marcel A.G. van der Heyden, Tessa J.M. Wijnhoven, Tobias Opthof

Date : 01/01/2005 Item size : 433811 bytes

Abstract Jose and Collison published a study on the normal range and the determinants of intrinsic heart rate in man in Cardiovascular Research in 1970 [Jose AD, Collison D. The normal range and ...

Cardiovascular Research, Update review, Tobias Opthof

Date : 01/01/2000 Item size : 362004 bytes

Abstract Aims Transgenic mice are frequently used to investigate the role of genes involved in cardiac conduction. Methods and results Ventricular activation and repolarization patterns generated by ...

Cardiovascular Research, Ion Channels and Arrythmias, Bas J. Boukens, Mark G. Hoogendijk, Arie O. Verkerk, Andre Linnenbank, Peter van Dam, Carol-Ann Remme, Jan W. Fiolet, Tobias Opthof, Vincent M. ...

Date : 01/01/2013 Item size : 280190 bytes

KeywordsConduction (block)Gap junctionsHisto(patho)logyImpulse formationSinus nodeTime for primary review 22 days. 1 Introduction The sinoatrial (SA) node requires a delicate balance of electrical ...

Cardiovascular Research, Original Article, Haruo Honjo, Mark R Boyett, Steven R Coppen, Yoshiko Takagishi, Tobias Opthof, Nicholas J Severs, Itsuo Kodama

Date : 01/01/2002 Item size : 255071 bytes

Next, we evaluate the consequences of alterations in expression and modulation of channel properties for cardiac function. [...]we have compared reports on genetically engineered animals and discuss ...

Cardiovascular Research, Review, Toon A.B. van Veen, Harold V.M. van Rijen, Tobias Opthof

Date : 01/08/2001 Item size : 615688 bytes

Introduction Heterogeneity of repolarization facilitates re-entrant arrhythmias.1,2 In the presence of a sufficiently large gradient of repolarization, a premature beat may cause re-entrant ...

Cardiovascular Research, Original Article, Tobias Opthof, Veronique M.F. Meijborg, Charly N.W. Belterman, Ruben Coronel

Date : 01/10/2015 Item size : 245145 bytes

The other paper focuses on the individual membrane currents in single cells isolated from the sinus node including the effects of noradrenaline and acetylcholine [2]. The first very practical piece ...

Cardiovascular Research, Editorial, Tobias Opthof

Date : 01/10/2001 Item size : 224503 bytes

Abstract Objectives: Loss of cardiac cells and the anatomical or functional remodeling of intercellular coupling occur under several pathological conditions. Treatment of the cultured myocytes at ...

Cardiovascular Research, Original Article, Kenji Yasui, Kenji Kada, Mayumi Hojo, Jong-Kook Lee, Kaichiro Kamiya, Junji Toyama, Tobias Opthof, Itsuo Kodama

Date : 01/10/2000 Item size : 273879 bytes

Journals with a high impact factor obtain this high value by frequent citation of only a limited number of their papers and, on the other hand, journals with low impact factors publish many papers ...

Cardiovascular Research, Editorial, Tobias Opthof, Ruben Coronel, Hans Michael Piper

Date : 01/02/2004 Item size : 152436 bytes