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Abstract Objective: The cytokine cardiotrophin-1 (CT-1) has previously been shown to protect cultured cardiocytes from cell death induced by serum removal or hypoxia when administered prior to the ...

Cardiovascular Research, Brar, Bhawanjit K, Stephanou, Anastasis, Liao, Zhihong, O'Leary, Rhona M, Pennica, Diane, Yellon, Derek M, Latchman, David S

Date : 01/08/2001

[...]the effects of disease states on this HS-induced cytoprotective response are less known. [...]we investigated the effects of prior heat stress on the infarct size in the isolated heart and on ...

Cardiovascular Research, Joyeux, Marie, Faure, Patrice, Godin-Ribuot, Diane, Halimi, Serge, Patel, Asha, Yellon, Derek M, Demenge, Pierre, Ribuot, Christophe

Date : 01/09/1999 Item size : 265245 bytes

Methods: To test the hypothesis that iNOS is necessary for delayed pharmacological preconditioning, the adenosine A1 receptor agonist, 2-chloro N6 cyclopentyl adenosine (CCPA) (25 μg/kg i.v.) or ...

Cardiovascular Research, Bell, Robert M, Smith, Christopher C.T, Yellon, Derek M

Date : 01/02/2002 Item size : 253287 bytes

Abstract Objective: The opening of the mitochondrial permeability transition pore (mPTP) in the first few minutes of post-ischaemic reperfusion is a critical determinant of reperfusion-induced cell ...

Cardiovascular Research, Hausenloy, Derek J, Duchen, Michael R, Yellon, Derek M

Date : 01/12/2003 Item size : 243929 bytes

To determine whether NO mediated protection was via opening of the putative mitochondrial KATP channel and/or free radical synthesis, SNAP perfused hearts were also treated with the mitochondrial ...

Cardiovascular Research, Bell, Robert M, Maddock, Helen L, Yellon, Derek M

Date : 01/02/2003

Abstract Heart failure is rapidly increasing in prevalence and will redraw the global landscape for cardiovascular health. Introduction Modern therapeutic advances in treating ischaemic heart ...

Cardiovascular Research, Ziff, Oliver J, Bromage, Daniel I, Yellon, Derek M, Davidson, Sean M

Date : 01/03/2018 Item size : 506607 bytes

In patients who experience an acute myocardial infarction (AMI), a greater extent of myocardial necrosis results in a worse long-term prognosis.1 It is therefore imperative to develop treatments that ...

Cardiovascular Research, Davidson, Sean M, Yellon, Derek M

Date : 01/05/2018 Item size : 157882 bytes