top
Search terms
Results 1 - 10 of 37 - ordered by :
Pages: 1 2 3 4
Ehjcardiovascrec

In patients who experience an acute myocardial infarction (AMI), a greater extent of myocardial necrosis results in a worse long-term prognosis.1 It is therefore imperative to develop treatments that ...

Cardiovascular Research, Davidson, Sean M, Yellon, Derek M

Date : 01/05/2018 Item size : 157882 bytes
Ehjcardiovascrec

Abstract Heart failure is rapidly increasing in prevalence and will redraw the global landscape for cardiovascular health. Introduction Modern therapeutic advances in treating ischaemic heart ...

Cardiovascular Research, Ziff, Oliver J, Bromage, Daniel I, Yellon, Derek M, Davidson, Sean M

Date : 01/03/2018 Item size : 506607 bytes
Ehjcardiovascrec

Introduction The phosphatidylinositol 3-OH kinase (PI3K)Akt [1,2], and the Rafmitogen activated protein kinase (MAPK), extracellular signal-regulated kinase (RafMEK1/2Erk1/2) cascades [3], are ...

Cardiovascular Research, Hausenloy, Derek J, Mocanu, Mihaela M, Yellon, Derek M

Date : 01/08/2004 Item size : 272820 bytes
Ehjcardiovascrec

Therapeutic strategies that target and attenuate reperfusion-induced cell death may provide novel pharmacological agents, which can be used as an adjunct to current reperfusion therapy, to limit ...

Cardiovascular Research, Hausenloy, Derek J, Yellon, Derek M

Date : 15/02/2004 Item size : 559838 bytes
Ehjcardiovascrec

Abstract Objective: The opening of the mitochondrial permeability transition pore (mPTP) in the first few minutes of post-ischaemic reperfusion is a critical determinant of reperfusion-induced cell ...

Cardiovascular Research, Hausenloy, Derek J, Duchen, Michael R, Yellon, Derek M

Date : 01/12/2003
Ehjcardiovascrec

Abstract Objective: The opening of the mitochondrial permeability transition pore (mPTP) in the first few minutes of post-ischaemic reperfusion is a critical determinant of reperfusion-induced cell ...

Cardiovascular Research, Hausenloy, Derek J, Duchen, Michael R, Yellon, Derek M

Date : 01/12/2003 Item size : 243929 bytes
Ehjcardiovascrec

To determine whether NO mediated protection was via opening of the putative mitochondrial KATP channel and/or free radical synthesis, SNAP perfused hearts were also treated with the mitochondrial ...

Cardiovascular Research, Bell, Robert M, Maddock, Helen L, Yellon, Derek M

Date : 01/02/2003
Ehjcardiovascrec

To determine whether NO mediated protection was via opening of the putative mitochondrial KATP channel and/or free radical synthesis, SNAP perfused hearts were also treated with the mitochondrial ...

Cardiovascular Research, Bell, Robert M, Maddock, Helen L, Yellon, Derek M

Date : 01/02/2003
Ehjcardiovascrec

Abstract The role of the mitochondrial ATP-sensitive potassium channel (mKATP) in ischemic preconditioning and cardioprotection is reviewed. Recent studies, however, reveal that channel opening can ...

Cardiovascular Research, Oldenburg, Olaf, Cohen, Michael V, Yellon, Derek M, Downey, James M

Date : 15/08/2002
Ehjcardiovascrec

Abstract Objective: We propose that ischemic preconditioning (IPC) and mitochondrial KATP channel activation protect the myocardium by inhibiting mitochondrial permeability transition pore (MPTP) ...

Cardiovascular Research, Hausenloy, Derek J, Maddock, Helen L, Baxter, Gary F, Yellon, Derek M

Date : 15/08/2002