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Ehjcardiovascrec

Abstract Objective: The opening of the mitochondrial permeability transition pore (mPTP) in the first few minutes of post-ischaemic reperfusion is a critical determinant of reperfusion-induced cell ...

Cardiovascular Research, Hausenloy, Derek J, Duchen, Michael R, Yellon, Derek M

Date : 01/12/2003
Ehjcardiovascrec

Introduction The phosphatidylinositol 3-OH kinase (PI3K)Akt [1,2], and the Rafmitogen activated protein kinase (MAPK), extracellular signal-regulated kinase (RafMEK1/2Erk1/2) cascades [3], are ...

Cardiovascular Research, Hausenloy, Derek J, Mocanu, Mihaela M, Yellon, Derek M

Date : 01/08/2004 Item size : 272820 bytes
Ehjcardiovascrec

Abstract Objective: We propose that ischemic preconditioning (IPC) and mitochondrial KATP channel activation protect the myocardium by inhibiting mitochondrial permeability transition pore (MPTP) ...

Cardiovascular Research, Hausenloy, Derek J, Maddock, Helen L, Baxter, Gary F, Yellon, Derek M

Date : 15/08/2002
Ehjcardiovascrec

Abstract Objective: We propose that ischemic preconditioning (IPC) and mitochondrial KATP channel activation protect the myocardium by inhibiting mitochondrial permeability transition pore (MPTP) ...

Cardiovascular Research, Hausenloy, Derek J, Maddock, Helen L, Baxter, Gary F, Yellon, Derek M

Date : 15/08/2002 Item size : 295447 bytes
Ehjcardiovascrec

Therapeutic strategies that target and attenuate reperfusion-induced cell death may provide novel pharmacological agents, which can be used as an adjunct to current reperfusion therapy, to limit ...

Cardiovascular Research, Hausenloy, Derek J, Yellon, Derek M

Date : 15/02/2004 Item size : 559838 bytes
Ehjcardiovascrec

Abstract Objective: The opening of the mitochondrial permeability transition pore (mPTP) in the first few minutes of post-ischaemic reperfusion is a critical determinant of reperfusion-induced cell ...

Cardiovascular Research, Hausenloy, Derek J, Duchen, Michael R, Yellon, Derek M

Date : 01/12/2003 Item size : 243929 bytes