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Ehjcardiovascrec

Conclusion: These results demonstrate for the first time that the mitoKATP channel opener diazoxide can act as a trigger of preconditioning by a mechanism involving mitochondrial swelling and the ...

Cardiovascular Research, Carroll, Richard, Gant, Vanya A, Yellon, Derek M

Date : 01/09/2001 Item size : 275299 bytes
Ehjcardiovascrec

Abstract Background: Recent studies have postulated that mitochondrial ATP-sensitive potassium (mitoKATP) channel activation may modulate mitochondrial function with the resultant induction of a ...

Cardiovascular Research, Minners, Jan, van den Bos, Ewout J, Yellon, Derek M, Schwalb, Herzl, Opie, Lionel H, Sack, Michael N

Date : 01/07/2000
Ehjcardiovascrec

Introduction The phosphatidylinositol 3-OH kinase (PI3K)Akt [1,2], and the Rafmitogen activated protein kinase (MAPK), extracellular signal-regulated kinase (RafMEK1/2Erk1/2) cascades [3], are ...

Cardiovascular Research, Hausenloy, Derek J, Mocanu, Mihaela M, Yellon, Derek M

Date : 01/08/2004 Item size : 272820 bytes
Ehjcardiovascrec

Abstract The role of the mitochondrial ATP-sensitive potassium channel (mKATP) in ischemic preconditioning and cardioprotection is reviewed. Recent studies, however, reveal that channel opening can ...

Cardiovascular Research, Oldenburg, Olaf, Cohen, Michael V, Yellon, Derek M, Downey, James M

Date : 15/08/2002
Ehjcardiovascrec

The phenomenon of ischaemic preconditioning, in which a period of sublethal ischemia can profoundly protect the cell from subsequent lethal ischemic insult, has without doubt been responsible for an ...

Cardiovascular Research, Yellon, Derek M, Downey, James M

Date : 15/08/2002 Item size : 205674 bytes
Ehjcardiovascrec

The phenomenon of ischaemic preconditioning, in which a period of sublethal ischemia can profoundly protect the cell from subsequent lethal ischemic insult, has without doubt been responsible for an ...

Cardiovascular Research, Yellon, Derek M, Downey, James M

Date : 15/08/2002 Item size : 179121 bytes
Ehjcardiovascrec

Abstract Background: Recent studies have postulated that mitochondrial ATP-sensitive potassium (mitoKATP) channel activation may modulate mitochondrial function with the resultant induction of a ...

Cardiovascular Research, Minners, Jan, van den Bos, Ewout J, Yellon, Derek M, Schwalb, Herzl, Opie, Lionel H, Sack, Michael N

Date : 01/07/2000
Ehjcardiovascrec

Conclusion: These results demonstrate for the first time that the mitoKATP channel opener diazoxide can act as a trigger of preconditioning by a mechanism involving mitochondrial swelling and the ...

Cardiovascular Research, Carroll, Richard, Gant, Vanya A, Yellon, Derek M

Date : 01/09/2001 Item size : 283733 bytes
Ehjcardiovascrec

Methods: To test the hypothesis that iNOS is necessary for delayed pharmacological preconditioning, the adenosine A1 receptor agonist, 2-chloro N6 cyclopentyl adenosine (CCPA) (25 μg/kg i.v.) or ...

Cardiovascular Research, Bell, Robert M, Smith, Christopher C.T, Yellon, Derek M

Date : 01/02/2002 Item size : 253287 bytes