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Abstract The ultrarapid delayed rectifier channels have attracted considerable interest as targets for atrial-selective antiarrhythmic drugs because they contribute to atrial but not to ventricular ...

Cardiovascular Research, REVIEWS: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Ursula Ravens, Erich Wettwer

Date : 01/03/2011 Item size : 504670 bytes

Introduction MicroRNAs (miRNAs or miRs) have become increasingly recognized as major regulators of various physiological processes.1 Recently, modulation of miR activity in the heart has been ...

Cardiovascular Research, Cardiac biology and remodelling, Yaoping Tang, Yongchao Wang, Kyoung-mi Park, Qiuping Hu, Jian-peng Teoh, Zuzana Broskova, Punithavathi Ranganathan, Calpurnia Jayakumar, Jie ...

Date : 01/06/2015 Item size : 470749 bytes

A subset of patients with dilated cardiomyopathy (DCM) have been shown to carry increased levels of autoantibodies against β-adrenoceptors, muscarinic receptors, Na+K+-ATPase, or troponin I.14 ...

Cardiovascular Research, Editorial, Jordi Heijman, Dobromir Dobrev

Date : 01/06/2013 Item size : 178343 bytes

Right cervical vagus nerve stimulation (VNS) was applied to determine its effects on the sinus rate, ventricular rate during atrial fibrillation, PR interval, atrial effective refractory period, and ...

Cardiovascular Research, Original Article, Baozhen Qi, Yong Wei, Songwen Chen, Genqing Zhou, Hongli Li, Juan Xu, Yu Ding, Xiaofeng Lu, Liqun Zhao, Feng Zhang, Gang Chen, Jing Zhao, Shaowen Liu

Date : 01/06/2014 Item size : 299112 bytes

Abstract Genome-wide association studies (GWAS) for atrial fibrillation (AF) have identified three distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 that are associated with the ...

Cardiovascular Research, REVIEWS: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Moritz F. Sinner, Patrick T. Ellinor, Thomas Meitinger, Emelia J. Benjamin, Stefan Kääb

Date : 01/03/2011 Item size : 424845 bytes

Furthermore, studies in humans suggest a protective role for HSPs against progression from paroxysmal AF to chronic, persistent AF. [...]manipulation of the HSP system may offer novel therapeutic ...

Cardiovascular Research, Review, Bianca J.J.M. Brundel, Lei Ke, Anne-Jan Dijkhuis, XiaoYan Qi, Akiko Shiroshita-Takeshita, Stanley Nattel, Robert H. Henning, Harm H. Kampinga

Date : 01/06/2008 Item size : 448399 bytes

Abstract Objective: We describe a genetic basis for atrial fibrillation and short QT syndrome in utero. Computer modeling showed that the mutation would shorten action potential duration of human ...

Cardiovascular Research, Original Article, Kui Hong, David R. Piper, Aurora Diaz-Valdecantos, Josep Brugada, Antonio Oliva, Elena Burashnikov, José Santos-de-Soto, Josefina Grueso-Montero, Ernesto ...

Date : 01/12/2005 Item size : 242456 bytes

Abstract Background: The L-type calcium channel (LCC) plays a crucial role in the electrical remodeling of atrial fibrillation (AF). [...]we performed a single LCC analysis to assess channel gating ...

Cardiovascular Research, Original Article, Gunnar Klein, Frank Schröder, David Vogler, Arnd Schaefer, Axel Haverich, Bernhard Schieffer, Thomas Korte, Helmut Drexler

Date : 01/07/2003 Item size : 239221 bytes

The prevalence of AF has been increasing, due to both ageing of the population and an increased prevalence of risk factors such as obesity and sedentary lifestyle. Many of the available ...

Cardiovascular Research, Editorial, David R. Van Wagoner

Date : 01/04/2013 Item size : 162016 bytes

A substrate for atrial propensity to AF is required for AF initiation and maintenance. [...]we reviewed and discussed mainly the electrophysiological properties observed in ...

Cardiovascular Research, Review, Akihiko Shimizu, Osmar Antonio Centurion

Date : 01/05/2002 Item size : 533491 bytes