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Furthermore, studies in humans suggest a protective role for HSPs against progression from paroxysmal AF to chronic, persistent AF. [...]manipulation of the HSP system may offer novel therapeutic ...

Cardiovascular Research, Review, Bianca J.J.M. Brundel, Lei Ke, Anne-Jan Dijkhuis, XiaoYan Qi, Akiko Shiroshita-Takeshita, Stanley Nattel, Robert H. Henning, Harm H. Kampinga

Date : 01/06/2008 Item size : 448399 bytes

Introduction 1.1 Proteostasis The proper function of cells depends critically on the maintenance of a healthy homeostasis of protein expression, folding, assembly, trafficking, and degradation, ...

Cardiovascular Research, INVITED SPOTLIGHT REVIEWS, Deli Zhang, Xu Hu, Robert H. Henning, Bianca J.J.M. Brundel

Date : 01/04/2016

Introduction Atrial fibrillation (AF) is a common cardiac arrhythmia associated with increased cardiovascular morbidity and mortality.13 Conventional anti-arrhythmic drugs often fail to provide ...

Cardiovascular Research, Original Article, Masao Sakabe, Akiko Shiroshita-Takeshita, Ange Maguy, Bianca J.J.M. Brundel, Akira Fujiki, Hiroshi Inoue, Stanley Nattel

Date : 01/04/2008

Abstract Background: There is evidence suggesting involvement of oxidative stress, inflammation, and calcineurin/nuclear factor of activated T cell pathways in atrial fibrillation. Dogs were ...

Cardiovascular Research, Original Article, Akiko Shiroshita-Takeshita, Bianca J.J.M. Brundel, Joel Lavoie, Stanley Nattel

Date : 01/03/2006

Results: L-type calcium channel α1 and sarcoplasmic reticulum Ca2+-ATPase mRNA (57%, p=0.01 and 28%, p=0.04, respectively) and protein contents (43%, p=0.02 and 28%, p=0.04, respectively) were ...

Cardiovascular Research, Original Article, Bianca J.J.M. Brundel, Isabelle C. Van Gelder, Robert H. Henning, Anton E. Tuinenburg, Leo E. Deelman, Robert G. Tieleman, Jan G. Grandjean, Wiek H. Van ...

Date : 01/05/1999

Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure Abstract Background: Congestive heart failure (CHF) is a common cause of atrial ...

Cardiovascular Research, Original Article, Akiko Shiroshita-Takeshita, Bianca J.J.M. Brundel, Brett Burstein, Tack-Ki Leung, Hideo Mitamura, Satoshi Ogawa, Stanley Nattel

Date : 01/04/2007