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Methods and results LA-remodelling was studied in dogs with heart failure (HF) induced by ventricular tachypacing (VTP, 240 bpm), and in mice with left-ventricular (LV) dysfunction due to myocardial ...

Cardiovascular Research, Chen, Yu, Surinkaew, Sirirat, Naud, Patrice, Qi, Xiao-Yan, Gillis, Marc-Antoine, Shi, Yan-Fen, Tardif, Jean-Claude, Dobrev, Dobromir, Nattel, Stanley

Date : 01/03/2017 Item size : 142189 bytes

In disease states, fibroblast production of increased quantities of ECM proteins leads to tissue fibrosis, which can impair both mechanical and electrical function of the heart, contributing to heart ...

Cardiovascular Research, Yue, Lixia, Xie, Jia, Nattel, Stanley

Date : 01/03/2011 Item size : 492471 bytes

Furthermore, studies in humans suggest a protective role for HSPs against progression from paroxysmal AF to chronic, persistent AF. [...]manipulation of the HSP system may offer novel therapeutic ...

Cardiovascular Research, Brundel, Bianca J.J.M., Ke, Lei, Dijkhuis, Anne-Jan, Qi, XiaoYan, Shiroshita-Takeshita, Akiko, Nattel, Stanley, Henning, Robert H., Kampinga, Harm H.

Date : 01/06/2008

Atrial fibrillation (AF) is the most common sustained clinical arrhythmia, and is an increasing problem in terms of prevalence, complications, and health costs.1 The options for treating AF are ...

Cardiovascular Research, Nattel, Stanley

Date : 01/06/2016 Item size : 96539 bytes

Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with substantial cardiovascular morbidity and mortality, with stroke being the most critical complication.1 Present drugs ...

Cardiovascular Research, Dobrev, Dobromir, Nattel, Stanley

Date : 01/03/2011 Item size : 158514 bytes

Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure Abstract Background: Congestive heart failure (CHF) is a common cause of atrial ...

Cardiovascular Research, Shiroshita-Takeshita, Akiko, Brundel, Bianca J.J.M., Burstein, Brett, Leung, Tack-Ki, Mitamura, Hideo, Ogawa, Satoshi, Nattel, Stanley

Date : 01/04/2007

Evolution of the atrial fibrillation substrate in experimental congestive heart failure: angiotensin-dependent and -independent pathways Protein expression was determined by Western blot, ...

Cardiovascular Research, Cardin, Sophie, Li, Danshi, Thorin-Trescases, Nathalie, Leung, Tack-Ki, Thorin, Eric, Nattel, Stanley

Date : 01/11/2003 Item size : 301637 bytes

Methods: Expression and distribution of the inward-rectifier subunits Kir2.1 and Kir2.3, the rapid delayed-rectifier α-subunit ERG, the slow delayed-rectifier α-subunit KvLQT1, the β-subunit ...

Cardiovascular Research, Melnyk, Peter, Ehrlich, Joachim R., Pourrier, Marc, Villeneuve, Louis, Cha, Tae-Joon, Nattel, Stanley

Date : 01/01/2005 Item size : 328011 bytes

Abstract Background: There is evidence suggesting involvement of oxidative stress, inflammation, and calcineurin/nuclear factor of activated T cell pathways in atrial fibrillation. Dogs were ...

Cardiovascular Research, Shiroshita-Takeshita, Akiko, Brundel, Bianca J.J.M., Lavoie, Joel, Nattel, Stanley

Date : 01/03/2006

Here, we assessed the differential expression of Kv currents between atrial and ventricular fibroblasts from control dogs and dogs with an atrial arrhythmogenic substrate caused by congestive heart ...

Cardiovascular Research, Wu, Chia-Tung, Qi, Xiao-Yan, Huang, Hai, Naud, Patrice, Dawson, Kristin, Yeh, Yung-Hsin, Harada, Masahide, Kuo, Chi-Tai, Nattel, Stanley

Date : 01/06/2014