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Factor Xa interacts with factor Va to convert prothrombin into thrombin. Besides their activity in coagulation, factor Xa and thrombin can signal through activation of PAR1 and PAR2 by proteolytic ...

Cardiovascular Research, TOPICAL REVIEW, Henri M.H. Spronk, Anne Margreet de Jong, Harry J. Crijns, Ulrich Schotten, Isabelle C. Van Gelder, Hugo ten Cate

Date : 01/03/2014 Item size : 350316 bytes

Atrial supply–demand balance in healthy adult pigs: coronary blood flow, oxygen extraction, and lactate production during acute atrial fibrillation Indirect evidence for supplydemand ischaemia ...

Cardiovascular Research, Integrative physiology and pathophysiology, Kelly A. van Bragt, Hussein M. Nasrallah, Marion Kuiper, Joost J. Luiken, Ulrich Schotten, Sander Verheule

Date : 01/01/2014 Item size : 294801 bytes

While it is well established that AF-induced changes in Ca2+ handling contribute to contractile remodelling, current research is focused on elucidating the role of altered intracellular Ca2+ handling ...

Cardiovascular Research, REVIEWS: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Maura Greiser, W. Jonathan Lederer, Ulrich Schotten

Date : 01/03/2011 Item size : 540078 bytes

Nishijima et al.1 recently published an article in Cardiovascular Research in which they described the effects of a treatment with the nitric oxide synthase (NOS) cofactor tetrahydrobiopterin (BH4) ...

Cardiovascular Research, Letter to the Editor, Harry J. Crijns, Ulrich Schotten, An L. Moens

Date : 01/08/2011 Item size : 135921 bytes

Abstract Background: AVE0118 (22-(4-Methoxy-phenyl)-acetylamino]-methyl}-biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)-amide) blocks atrial ultrarapid delayed rectifier currents (IKur) and ...

Cardiovascular Research, Rapid Communication, Ulrich Schotten, Sunniva de Haan, Sander Verheule, Erik G.A. Harks, Dirk Frechen, Eva Bodewig, Maura Greiser, Rashmi Ram, Jos Maessen, Malte Kelm, ...

Date : 01/01/2007

In previous years, disruption of electrical coupling between cardiac myocytes and muscle bundles, resulting in narrowerand thus morefibrillation waves, was identified as the main mechanism underlying ...

Cardiovascular Research, Editorial, Jens Eckstein, Ulrich Schotten

Date : 01/04/2012

Methods: From the right atrial appendages of 59 consecutive patients undergoing mitral valve surgery (31 in SR, 28 in chronic AF) thin muscle preparations (diameter<0.7 mm) were ...

Cardiovascular Research, Original Article, Ulrich Schotten, Maura Greiser, Dirk Benke, Kai Buerkel, Britta Ehrenteidt, Christoph Stellbrink, Jaime F Vazquez-Jimenez, Friedrich Schoendube, Peter ...

Date : 01/01/2002

Atrial structural remodeling also occurs as a result of heart failure and other underlying cardiovascular diseases. The associated atrial fibrosis might explain intra-atrial conduction disturbances ...

Cardiovascular Research, Review, Maurits Allessie, Jannie Ausma, Ulrich Schotten

Date : 01/05/2002

Over decades of research, a vast amount of knowledge has been gathered about the causes and consequences of AF related to cellular electrophysiology and features of the tissue structure that ...

Cardiovascular Research, INVITED SPOTLIGHT REVIEWS, Dragan Opacic, Kelly A. van Bragt, Hussein M. Nasrallah, Ulrich Schotten, Sander Verheule

Date : 01/04/2016