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Abstract Objective: The left human atrium plays an important role in initiation of atrial fibrillation (AF) and the hyperpolarization activated cation current (If) is a candidate for contributing to ...

Cardiovascular Research, Research Article, Klaus Zorn-Pauly, Peter Schaffer, Brigitte Pelzmann, Petra Lang, Heinrich Mächler, Bruno Rigler, Bernd Koidl

Date : 01/11/2004 Item size : 261977 bytes

[...]as we hope that the previous section has highlighted, to generalize oxidative stress as one single biological entity is counterproductive for the understanding of both the mechanism of action by ...

Cardiovascular Research, INVITED SPOTLIGHT REVIEWS, Jillian N. Simon, Klemen Ziberna, Barbara Casadei

Date : 01/04/2016 Item size : 519469 bytes

While it is well established that AF-induced changes in Ca2+ handling contribute to contractile remodelling, current research is focused on elucidating the role of altered intracellular Ca2+ handling ...

Cardiovascular Research, REVIEWS: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Maura Greiser, W. Jonathan Lederer, Ulrich Schotten

Date : 01/03/2011 Item size : 540078 bytes

Abstract The ultrarapid delayed rectifier channels have attracted considerable interest as targets for atrial-selective antiarrhythmic drugs because they contribute to atrial but not to ventricular ...

Cardiovascular Research, REVIEWS: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Ursula Ravens, Erich Wettwer

Date : 01/03/2011 Item size : 504670 bytes

[...]Sp mice exhibited increased atrial ectopy and susceptibility to pacing-induced AF, both of which were also prevented by the RyR2 S2814A mutation. Previously, studies have found that protein ...

Cardiovascular Research, Ion channels and arrhythmias, David Y. Chiang, Na Li, Qiongling Wang, Katherina M. Alsina, Ann P. Quick, Julia O. Reynolds, Guoliang Wang, Darlene Skapura, Niels Voigt, ...

Date : 01/07/2014 Item size : 333015 bytes

The potential relevance of increased incidence of spontaneous SR Ca2+ release for both AF induction and/or maintenance and the development of novel mechanism-based therapeutic approaches will be ...

Cardiovascular Research, REVIEWS: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Dobromir Dobrev, Niels Voigt, Xander H.T. Wehrens

Date : 01/03/2011 Item size : 506157 bytes

Abstract In the heart, changes in velocity and in patterns of conduction of myocardial electrical activity can affect cardiac rhythm and the coordination of contraction. Gap junctions are clusters ...

Cardiovascular Research, Review, Huub M.W van der Velden, Habo J Jongsma

Date : 01/05/2002 Item size : 372493 bytes

Expressed levels of cGMP-dependent protein kinase (PKG) were determined by Western blotting using PKG specific antibody in homogenates from atrial and ventricular cells. GSNO produced an additive ...

Cardiovascular Research, Original Article, Yang-gan Wang, Mary B. Wagner, Ronald W. Joyner, Rajiv Kumar

Date : 01/11/2000

Introduction Current options for pharmacological therapy of atrial fibrillation (AF) are limited by low efficacy and side effects, including life-threatening ventricular arrhythmias and severe ...

Cardiovascular Research, Ion channels and arrhythmias, Lasse Skibsbye, Claire Poulet, Jonas Goldin Diness, Bo Hjorth Bentzen, Lei Yuan, Utz Kappert, Klaus Matschke, Erich Wettwer, Ursula Ravens, ...

Date : 01/07/2014

Abstract Aims Na+ channel blockers are often used to treat atrial fibrillation (AF), but may sometimes cause ventricular contractile dysfunction. Methods and results Na+ currents (INa) were measured ...

Cardiovascular Research, Ion channels and arrhythmias, Tomoyuki Suzuki, Mikio Morishima, Sara Kato, Norihiro Ueda, Haruo Honjo, Kaichiro Kamiya

Date : 01/04/2013