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A substrate for atrial propensity to AF is required for AF initiation and maintenance. [...]we reviewed and discussed mainly the electrophysiological properties observed in ...

Cardiovascular Research, Review, Akihiko Shimizu, Osmar Antonio Centurion

Date : 01/05/2002 Item size : 533491 bytes

Calpain activity correlated with L-type Ca2+ channel and Kv1.5 protein amounts (r=0.80, P<0.001 and r=0.72, P<0.001, respectively), degree of structural changes (r=0.90, P<0.001), shortening of ...

Cardiovascular Research, Original Article, Bianca J.J.M Brundel, Jannie Ausma, Isabelle C van Gelder, Johan J.L Van Der Want, Wiek H van Gilst, Harry J.G.M Crijns, Robert H Henning

Date : 01/05/2002 Item size : 282302 bytes

The identification of the molecular structure of many ion channels involved in cardiac excitability and their functional correlation with native ionic currents have made it possible to study the ...

Cardiovascular Research, Review, Ralph F Bosch, Stanley Nattel

Date : 01/05/2002 Item size : 503601 bytes

Introduction Experimental and clinical studies have established that atrial fibrillation (AF) induces a shortening of atrial refractoriness (electrical remodeling) [1,2]. If the relative ...

Cardiovascular Research, Original Article, M. Duytschaever, Y. Blaauw, M. Allessie

Date : 01/07/2005

Abstract Objective In electrically remodeled atria the effect of blockers of the delayed rectifier K+ current IKr on repolarization is reduced, whereas the efficacy of early class III drugs ...

Cardiovascular Research, Original Article, Y. Blaauw, U. Schotten, A. van Hunnik, H.R. Neuberger, M.A. Allessie

Date : 01/07/2007

After a 5-day recovery period, rapid atrial pacing at 400 ppm was started, followed 2 days later by oral verapamil (8 mg/kg per day) in eight dogs (After group; A). [...]in B, these parameters did ...

Cardiovascular Research, Original Article, Yasuo Kurita, Hideo Mitamura, Akiko Shiroshita-Takeshita, Akiko Yamane, Masaki Ieda, Osamu Kinebuchi, Toshiaki Sato, Shunichiro Miyoshi, Motoki Hara, Seiji ...

Date : 01/05/2002

Methods: Action potentials (AP) and ionic currents were studied with the patch clamp technique in single atrial myocytes from patients in chronic AF and compared to those from patients in stable ...

Cardiovascular Research, Original Article, Ralph F. Bosch, Xiaorong Zeng, Joachim B. Grammer, Katarina Popovic, Christian Mewis, Volker Kühlkamp

Date : 01/10/1999

The exact origin and the behavior of such wavelets is a source of intense ongoing investigation utilizing experimental and computational approaches. 1 Cellular electrophysiological changes due to AF ...

Cardiovascular Research, Editorial, Kalyanam Shivkumar, James N Weiss

Date : 01/11/2001

In the article elsewhere in this issue, Ionic mechanisms of electrical remodeling in human atrial fibrillation Ralph Bosch and co-workers [1] describe the changes in atrial action potential ...

Cardiovascular Research, Editorial, Maurits A Allessie

Date : 01/10/1999

Steady-state and nonsteady-state action potentials in fibrillating canine atrium: abnormal rate adaptation and its possible mechanisms Abstract Objective: Our goal was to study rate adaptation of ...

Cardiovascular Research, Original Article, Motoki Hara, Alexei Shvilkin, Michael R Rosen, Peter Danilo, Penelope A Boyden

Date : 01/05/1999