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A subset of patients with dilated cardiomyopathy (DCM) have been shown to carry increased levels of autoantibodies against β-adrenoceptors, muscarinic receptors, Na+K+-ATPase, or troponin I.14 ...

Cardiovascular Research, Editorial, Jordi Heijman, Dobromir Dobrev

Date : 01/06/2013 Item size : 178343 bytes

[...]Sp mice exhibited increased atrial ectopy and susceptibility to pacing-induced AF, both of which were also prevented by the RyR2 S2814A mutation. Previously, studies have found that protein ...

Cardiovascular Research, Ion channels and arrhythmias, David Y. Chiang, Na Li, Qiongling Wang, Katherina M. Alsina, Ann P. Quick, Julia O. Reynolds, Guoliang Wang, Darlene Skapura, Niels Voigt, ...

Date : 01/07/2014 Item size : 333015 bytes

The potential relevance of increased incidence of spontaneous SR Ca2+ release for both AF induction and/or maintenance and the development of novel mechanism-based therapeutic approaches will be ...

Cardiovascular Research, REVIEWS: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Dobromir Dobrev, Niels Voigt, Xander H.T. Wehrens

Date : 01/03/2011 Item size : 506157 bytes

Introduction Nitric oxide (NO) synthetized by essentially all cardiac cell types is an ubiquitous cellular messenger that plays a key role in regulating cardiac function.15 NO is a highly diffusible ...

Cardiovascular Research, Review, Juan Tamargo, Ricardo Caballero, Ricardo Gómez, Eva Delpón

Date : 01/09/2010 Item size : 436503 bytes

Emergent evidence suggests that CaMKII may play an important role in promoting atrial fibrillation (AF) by targeting a diverse array of proteins involved in membrane excitability, cell survival, ...

Cardiovascular Research, INVITED SPOTLIGHT REVIEWS, Olurotimi O. Mesubi, Mark E. Anderson

Date : 01/04/2016

Expressed levels of cGMP-dependent protein kinase (PKG) were determined by Western blotting using PKG specific antibody in homogenates from atrial and ventricular cells. GSNO produced an additive ...

Cardiovascular Research, Original Article, Yang-gan Wang, Mary B. Wagner, Ronald W. Joyner, Rajiv Kumar

Date : 01/11/2000

FRET measurements revealed increased cAMP levels upon ATX-II stimulation, which could be prevented by inhibition of adenylyl cyclases (ACs) 5 and 6 (NKY 80) but not by inhibition of ...

Cardiovascular Research, Ion channels and arrhythmias, Thomas H. Fischer, Jonas Herting, Fleur E. Mason, Nico Hartmann, Saera Watanabe, Viacheslav O. Nikolaev, Julia U. Sprenger, Peidong Fan, Lina ...

Date : 01/07/2015

The SNAP effect on ICa,L involved activation of soluble guanylate cyclase and protein kinase A. Specific inhibition of phosphodiesterase (PDE)3 with cilostamide (1 µM) enhanced ICa,L to a similar ...

Cardiovascular Research, Ion channels and arrhythmias, Nadiia Rozmaritsa, Torsten Christ, David R. Van Wagoner, Hannelore Haase, Johannes-Peter Stasch, Klaus Matschke, Ursula Ravens

Date : 01/03/2014

[...]the specific role of the LKB1 pathway in early atrial biology remains unknown. [...]we investigated whether LKB1 deletion altered atrial channel expression and electrophysiological function in ...

Cardiovascular Research, Original Article, Grace E. Kim, Jenna L. Ross, Chaoqin Xie, Kevin N. Su, Vlad G. Zaha, Xiaohong Wu, Monica Palmeri, Mohammed Ashraf, Joseph G. Akar, Kerry S. Russell, Fadi G. ...

Date : 01/10/2015

[...]the therapeutic potential of I-1 in heart failure and arrhythmias has recently been addressed by the generation and analysis of several I-1 genetic mouse models. Introduction The prevalence of ...

Cardiovascular Research, Wittköpper, Katrin, Dobrev, Dobromir, Eschenhagen, Thomas, El-Armouche, Ali

Date : 01/08/2011 Item size : 429005 bytes