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While it is well established that AF-induced changes in Ca2+ handling contribute to contractile remodelling, current research is focused on elucidating the role of altered intracellular Ca2+ handling ...

Cardiovascular Research, REVIEWS: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Maura Greiser, W. Jonathan Lederer, Ulrich Schotten

Date : 01/03/2011 Item size : 540078 bytes

The potential relevance of increased incidence of spontaneous SR Ca2+ release for both AF induction and/or maintenance and the development of novel mechanism-based therapeutic approaches will be ...

Cardiovascular Research, REVIEWS: FOCUS ON THE MOLECULAR BASIS OF ATRIAL FIBRILLATION, Dobromir Dobrev, Niels Voigt, Xander H.T. Wehrens

Date : 01/03/2011 Item size : 506157 bytes

Introduction Nitric oxide (NO) synthetized by essentially all cardiac cell types is an ubiquitous cellular messenger that plays a key role in regulating cardiac function.15 NO is a highly diffusible ...

Cardiovascular Research, Review, Juan Tamargo, Ricardo Caballero, Ricardo Gómez, Eva Delpón

Date : 01/09/2010 Item size : 436503 bytes

Abstract Background: AVE0118 (22-(4-Methoxy-phenyl)-acetylamino]-methyl}-biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)-amide) blocks atrial ultrarapid delayed rectifier currents (IKur) and ...

Cardiovascular Research, Rapid Communication, Ulrich Schotten, Sunniva de Haan, Sander Verheule, Erik G.A. Harks, Dirk Frechen, Eva Bodewig, Maura Greiser, Rashmi Ram, Jos Maessen, Malte Kelm, ...

Date : 01/01/2007

Expressed levels of cGMP-dependent protein kinase (PKG) were determined by Western blotting using PKG specific antibody in homogenates from atrial and ventricular cells. GSNO produced an additive ...

Cardiovascular Research, Original Article, Yang-gan Wang, Mary B. Wagner, Ronald W. Joyner, Rajiv Kumar

Date : 01/11/2000

Abstract Aims Na+ channel blockers are often used to treat atrial fibrillation (AF), but may sometimes cause ventricular contractile dysfunction. Methods and results Na+ currents (INa) were measured ...

Cardiovascular Research, Ion channels and arrhythmias, Tomoyuki Suzuki, Mikio Morishima, Sara Kato, Norihiro Ueda, Haruo Honjo, Kaichiro Kamiya

Date : 01/04/2013

[...]a better understanding of the significance, role and regulation of these myolytic myocytes in the pathogenesis of AF is of major clinical importance. Using various immunohistological staining ...

Cardiovascular Research, Original Article, Catherine Rücker-Martin, Françoise Pecker, David Godreau, Stéphane N Hatem

Date : 01/07/2002

The first possibility is that an imbalance of sympathetic innervation (defined broadly to encompass different densities of sympathetic nerves, receptors, components of second messenger cascades, ...

Cardiovascular Research, Gilmour, Robert F

Date : 01/09/2001 Item size : 132894 bytes

In general, it appears that cells can rapidly (within minutes) change the number of functional channels at the cell surface through multiple mechanisms involving mobilization of intracellular ...

Cardiovascular Research, Musters, René J.P.

Date : 01/10/2006 Item size : 174090 bytes

Among the genes encoding the proteins underlying these currents, HERG codes for the K+ channel generating IKr, the target of class III antiarrhythmic drugs. Since this gene is also expressed at the ...

Cardiovascular Research, Baró, Isabelle

Date : 01/10/2006 Item size : 151055 bytes