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An ideal animal model for any cardiovascular disease in humans should have five characteristics: (i) mimic the human disease, (ii) allow studies in chronic, stable disease, (iii) produce symptoms ...

Cardiovascular Research, Review, Sheila A Doggrell, Lindsay Brown

Date : 01/07/1998 Item size : 693819 bytes

The widely used model is the spontaneous hypertensive rat (SHR) with a polygenic determination of hypertension has been a useful tool for the study of pathophysiological alterations in hypertensive ...

Cardiovascular Research, Original Article, Oliver Zolk, Markus Flesch, Georg Nickenig, Petra Schnabel, Michael Böhm

Date : 01/07/1998 Item size : 587738 bytes

In the present studies, eprosartan's ability to provide end-organ protection was evaluated in a model of cardiomyopathy and renal failure in stroke-prone rats (SP). Echocardiographic (i.e. 2-D ...

Cardiovascular Research, Original Article, Frank C. Barone, Robert W. Coatney, Sudeep Chandra, Susanta K. Sarkar, Allen H. Nelson, Lisa C. Contino, David P. Brooks, Wallace G. Campbell, Eliot H. ...

Date : 01/06/2001 Item size : 322347 bytes

Fortunately, drug therapy along with dietary and lifestyle changes can reduce blood pressure and, therefore, the complications of hypertension in most individuals. While the precise cause of ...

Cardiovascular Research, Editorial, Jawahar L. Mehta, Zufeng Ding, Shijie Liu, Xianwei Wang, Magomed Khaidakov

Date : 01/07/2014 Item size : 175047 bytes

Methods: Male homozygous ANP deficient (Nppa and wildtype (Nppa+/+) male mice maintained on either a normal salt (0.55% NaCl) or low salt (0.05% NaCl) diet from weaning were studied after 2 weeks of ...

Cardiovascular Research, Original Article, Tatsuhiko Mori, Yiu-Fai Chen, Ji An Feng, Tetsuya Hayashi, Suzanne Oparil, Gilbert J Perry

Date : 01/03/2004 Item size : 295112 bytes

Corticosteroid effects on phenylephrine and phorbol ester-induced hypertrophy were determined by measuring atrial natriuretic peptide (ANP) mRNA expression, protein synthesis, or induction of rDNA ...

Cardiovascular Research, Original Article, Kerrie Lister, Dominic J. Autelitano, Anna Jenkins, Ross D. Hannan, Karen E. Sheppard

Date : 01/06/2006 Item size : 371511 bytes

Understanding the signaling mechanisms of these receptors in the context of the heart is likely to provide a better therapeutic approach towards treatment of heart failure. Introduction Activation ...

Cardiovascular Research, Review, Liza Barki-Harrington, Cinzia Perrino, Howard A Rockman

Date : 15/08/2004 Item size : 572672 bytes

Abstract Objectives: We tested the hypothesis that a reduction in myocardial cyclic GMP would increase myocardial O2 consumption and that renal hypertension (One Kidney-One Clip, 1K1C)-induced ...

Cardiovascular Research, Original Article, John D. Sadoff, Peter M. Scholz, James Tse, Harvey R. Weiss

Date : 01/12/1997

Abstract Aims We investigated the effects of iptakalim, a new ATP-sensitive potassium channel (KATP) opener providing endothelial protection, on the progression of cardiac hypertrophy to failure in a ...

Cardiovascular Research, Original Article, Shan Gao, Chao-Liang Long, Ru-Huan Wang, Hai Wang

Date : 01/08/2009

KeywordsAutonomic nervous systemCardiomyopathyHeart failureHypertrophyReceptorsSignal transductionTime for primary review 33 days. 1 Introduction Sympathoadrenergic signals to the heart are detected ...

Cardiovascular Research, Review, Xiao-Jun Du

Date : 01/06/2001