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The goal of this review is to summarize the available information regarding the mechanism whereby PI3Kγ exerts blood pressure control, regulating myogenic tone at the level of L-type calcium ...

Cardiovascular Research, Review, Daniela Carnevale, Giuseppe Lembo

Date : 01/09/2012 Item size : 308134 bytes

[...]AT2 receptor stimulation inhibits growth and promotes apoptosis, an important mechanism during development and tissue remodeling. [...]ANG stimulates the release of nitric oxide (NO)/cGMP via ...

Cardiovascular Research, Review, Olaf Jöhren, Andreas Dendorfer, Peter Dominiak

Date : 01/06/2004 Item size : 423872 bytes

Yet, while modulation of cGMP-PKG has entered clinical practice for treating pulmonary hypertension or erectile dysfunction, translation of promising studies in experimental HF to clinical success ...

Cardiovascular Research, Review, Peter P. Rainer, David A. Kass

Date : 15/07/2016 Item size : 575491 bytes

Understanding the signaling mechanisms of these receptors in the context of the heart is likely to provide a better therapeutic approach towards treatment of heart failure. Introduction Activation ...

Cardiovascular Research, Review, Liza Barki-Harrington, Cinzia Perrino, Howard A Rockman

Date : 15/08/2004 Item size : 572672 bytes

To elucidate the role of IRAG for NO- and ANP-mediated smooth muscle tone regulation, cGKI localization, and for its possible function in blood pressure adjustment, we generated IRAG-knockout mice by ...

Cardiovascular Research, Original Article, Matthias Desch, Katja Sigl, Bernhard Hieke, Katharina Salb, Frieder Kees, Dominik Bernhard, Angela Jochim, Beate Spiessberger, Klaus Höcherl, Robert ...

Date : 01/06/2010

Overexpression of PKCβ2 is associated with increased expression of connective tissue growth factor (CTGF) in myocardium, resulting in myocardial hypertrophy. Introduction Evidence suggests that ...

Cardiovascular Research, Original Article, Zhengyuan Xia, Kuo-Hsing Kuo, Prabhakara R. Nagareddy, Fang Wang, Zhixin Guo, Tianhai Guo, Jihong Jiang, John H. McNeill

Date : 01/03/2007

Methods and results Two novel antibodies against the short peptides CP-7, which is located in the second extracellular loop of α1A-AR, and CPE-8, which is located in the third extracellular loop ...

Cardiovascular Research, Original Article, Fen Chen, Xiao Chen, Zhihua Qiu, Min Wang, Shijun Yang, Mustafa Khamis, Miao Yu, Xian Yu, Zuxia Liu, Lan Wang, Zihua Zhou, Yuhua Liao

Date : 01/02/2012

Abstract Aims Membrane potential is a key determinant of vascular tone and many vasodilators act through the modulation of ion channel currents [e.g. the ATP-sensitive potassium channel (KATP)] ...

Cardiovascular Research, Original Article, Carl P. Nelson, Richard D. Rainbow, Jennifer L. Brignell, Matthew D. Perry, Jonathon M. Willets, Noel W. Davies, Nicholas B. Standen, R.A. John Challiss

Date : 01/09/2011

Protection can be performed either by an ischemic stimulus of the heart itself or by ischemia of an organ distant to the heart (remote PC). Focus of the present study was to address the question ...

Cardiovascular Research, Original Article, Christof Weinbrenner, Falk Schulze, László Sárváry, Ruth H Strasser

Date : 15/02/2004

Abstract Objective: Cardiovascular risk is increased among HIV-infected patients receiving antiretroviral therapy due to the development of hypertension and metabolic abnormalities. In this study, ...

Cardiovascular Research, Original Article, Italia Papparella, Giulio Ceolotto, Laura Berto, Maurizio Cavalli, Sergio Bova, Gabriella Cargnelli, Ezia Ruga, Ornella Milanesi, Lorenzo Franco, Martina ...

Date : 15/01/2007