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KeywordsDilated cardiomyopathyHeart failureCardiac performanceAcromegalyTime for primary review 31 days. 1 Introduction Growth hormone (GH) controls linear growth and a variety of other functions, ...

Cardiovascular Research, Review, Luigi Saccà

Date : 01/10/1997 Item size : 322191 bytes

[...]overshooting activation is likely to have negative long-term effects [2]. [...]it is worth to investigate whether disturbances of the myocardial Ca2+ homeostasis, which occur in experimental ...

Cardiovascular Research, Original Article, Hans Reinecke, Roland Vetter, Helmut Drexler

Date : 01/11/1997 Item size : 245260 bytes

Abstract Aims Stimulation of β-adrenergic receptors (β-AR) increases cAMP production and contributes to the pathogenesis of cardiac hypertrophy and failure through poorly understood ...

Cardiovascular Research, Cardiac biology and remodelling, Anne-Coline Laurent, Malik Bisserier, Alexandre Lucas, Florence Tortosa, Marie Roumieux, Annélie De Régibus, Audrey Swiader, Yannis ...

Date : 01/01/2015 Item size : 311173 bytes

Abstract Aims Accumulating evidence suggest that sarcomere signalling complexes play a pivotal role in cardiomyocyte hypertrophy by communicating stress signals to the nucleus to induce gene ...

Cardiovascular Research, Original Article, Lin Zhong, Manuel Chiusa, Adrian G. Cadar, Angel Lin, Susan Samaras, Jeffrey M. Davidson, Chee C. Lim

Date : 01/05/2015 Item size : 330143 bytes

[...]pharmacological modifications of parallel and interdependent signalling components, such as the AMP-activated protein kinase pathway, are now considered to be a good therapeutic approach to ...

Cardiovascular Research, Review, Luc Bertrand, Sandrine Horman, Christophe Beauloye, Jean-Louis Vanoverschelde

Date : 15/07/2008 Item size : 617408 bytes

An ideal animal model for any cardiovascular disease in humans should have five characteristics: (i) mimic the human disease, (ii) allow studies in chronic, stable disease, (iii) produce symptoms ...

Cardiovascular Research, Review, Sheila A Doggrell, Lindsay Brown

Date : 01/07/1998 Item size : 693819 bytes

The widely used model is the spontaneous hypertensive rat (SHR) with a polygenic determination of hypertension has been a useful tool for the study of pathophysiological alterations in hypertensive ...

Cardiovascular Research, Original Article, Oliver Zolk, Markus Flesch, Georg Nickenig, Petra Schnabel, Michael Böhm

Date : 01/07/1998 Item size : 587738 bytes

Chamber specification is tightly co-ordinated by temporal and spatial expression of cardiac transcription factors such as T-box transcription factor 5 (Tbx5), GATA-binding protein 4 (Gata4), Myocyte ...

Cardiovascular Research, TOPICAL REVIEW, Prabhu Mathiyalagan, Samuel T. Keating, Xiao-Jun Du, Assam El-Osta

Date : 01/07/2014 Item size : 624022 bytes

Conclusion: Data show that SR Ca2+ release and SR Ca2+ content were increased in hypertrophied myocytes, despite an increase in the steady state INa/Ca density. The observation that increased SR ...

Cardiovascular Research, Original Article, Alzbeta Chorvatova, George Hart, Munir Hussain

Date : 01/02/2004 Item size : 266773 bytes

[...]the identification of key processes setting off a cascade of detrimental cellular changes, ultimately leading to the development of cardiac failure, is still subject of intense research. The ...

Cardiovascular Research, Review, Marc van Bilsen, Pascal J.H Smeets, Andries J Gilde, Ger J van der Vusse

Date : 01/02/2004 Item size : 428514 bytes