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An ideal animal model for any cardiovascular disease in humans should have five characteristics: (i) mimic the human disease, (ii) allow studies in chronic, stable disease, (iii) produce symptoms ...

Cardiovascular Research, Review, Sheila A Doggrell, Lindsay Brown

Date : 01/07/1998 Item size : 693819 bytes

The implication of chronic inflammation in the pathogenesis of atherosclerotic lesions was initially proposed by Virchow9 in the mid-nineteenth century and evolved over the next century into the ...

Cardiovascular Research, Review, Stavros Apostolakis, Konstantina Vogiatzi, Virginia Amanatidou, Demetrios A. Spandidos

Date : 01/12/2009 Item size : 388218 bytes

Abstract The G protein-coupled receptor kinases (GRKs) participate with arrestins in the regulation and signal propagation of multiple G protein-coupled receptors (GPCR) of key physiological and ...

Cardiovascular Research, Review, Petronila Penela, Cristina Murga, Catalina Ribas, Antonio S. Tutor, Sandra Peregrín, Federico Mayor

Date : 01/01/2006 Item size : 407122 bytes

Abstract Aldosterone is well recognized as a cause of sodium reabsorption, water retention, and potassium and magnesium loss; however, it also produces a variety of other actions that lead to ...

Cardiovascular Research, Review, Allan D Struthers, Thomas M MacDonald

Date : 01/03/2004 Item size : 333477 bytes

Whereas clinical research on human subjects has been important at the level of the application of knowledge at the bedside, the fundamental discoveries have been the result of basic science. Since ...

Cardiovascular Research, Editorial, James C Russell

Date : 01/10/2003 Item size : 150783 bytes

Pre-menopausal women have a lower risk of developing hypertension than men or post-menopausal women [1]. [...]animal models such as the spontaneously hypertensive rat (SHR) exhibit sexual dichotomy ...

Cardiovascular Research, Editorial, C. Subah Packer

Date : 01/01/2007 Item size : 156972 bytes

Introduction Despite improved management and availability of conventional therapies, cardiovascular disease remains the leading cause of death in the Western world. Furthermore, as the incidence of ...

Cardiovascular Research, Original Article, Ian B. Copland, E. Marc Jolicoeur, Marc-Antoine Gillis, Jessica Cuerquis, Nicoletta Eliopoulos, Borhane Annabi, Angelo Calderone, Jean-Francois Tanguay, ...

Date : 01/08/2008 Item size : 322215 bytes

In addition to their lipid-lowering effects, one central biological action of statins is their ability to ameliorate the impaired bioavailability of NO.1 Mechanistically, this occurs through ...

Cardiovascular Research, Editorial, Stephan H. Schirmer, Christian M. Werner, Ulrich Laufs, Michael Böhm

Date : 01/06/2012 Item size : 181712 bytes

Despite major advances in the understanding of cardiovascular physiology and pathophysiology and the development of new therapies in the 20th century, cardiovascular disease is projected to become ...

Cardiovascular Research, Review, Ajay M Shah, Steven J Sollott, Edward G Lakatta

Date : 01/07/1998

Abstract Cardiac societies recommend the intake of 1 g/day of the two omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) for cardiovascular disease prevention, ...

Cardiovascular Research, Review, Clemens von Schacky, William S. Harris

Date : 15/01/2007